UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934 (Amendment No. )
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INVITAE CORPORATION
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
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Invitae Corporation 1400 16th Street |
April 21, 202219, 2023
Dear Stockholder:To our stockholders,
2022 was transformative for Invitae, and we passed several milestones along the way. We finished the year having served over 3.6 million patients in total since our founding. Additionally, information from over 2.3 million patients has been made available for sharing, in support of our core tenets that patients own their data and that data is more valuable when shared. From a customer standpoint, we wrapped up 2022 with over 20,000 health systems, institutions, clinics, and providers actively ordering from us. We are more and more focused on how we provide value for customers who share our vision to bring accessible and affordable genetic information into healthcare. Finally, our full year 2022 revenue crossed the discovery$500 million threshold for the first time. These milestones are important, and come with them an acknowledgement of the DNA double stranded helixprivilege we have to be of service to so many. Invitaens believe in our mission, care deeply for the Human Genome project, which providedhealth outcomes of patients, and also embrace our fundamental responsibility to deliver long–term value for our stockholders.
In 2022, we also delivered a blueprintmajor strategic realignment, executed to reshape Invitae and set us on a path to operational excellence, profitable growth, cash preservation, and focused investment in support of our biology, wemost promising opportunities. We are pleased that the major initiatives under our strategic realignment are now engagedlargely completed. These changes have unlocked improved margins and reduced cash consumption, and were done with swift execution and courage by our dedicated and committed teams.
The transformation does not end there. Already in 2023 we have taken steps to put the company on a race to define a new meansmore solid financial footing by addressing our short term debt maturities, including the repayment of understanding and improving health and medicine. Over the past decade, medical genetics has informed and improved the lives of millions of patients, but the next 10 years is expected to usherour senior term loan in a new age of healthcare innovation and practice in which nearly every person will benefit from the understanding of that blueprint to foresee and act upon their risks, specifically address their conditions and improve their health outlook.full.
The developmentOur mission — to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of hundredspeople — has not changed. I’d like to thank our many stockholders, investors, customers, patients, and employees for their continued support of genomic tests has been an important stepping-stone toward this new era, but those tests onour mission, and for their own represent only the raw inputs of where genomic medicine is going,belief and Invitae is doingconfidence in the important work that we are doing at Invitae. We are now moving forward, with a refined focus and strategy to connect personal and population-based genetic data to every aspect of medicine and the healthcare ecosystem, ushering in the genomic medicine era - today.deliver sustainable growth as we go about reaching our long-term goals.
OurAnd, speaking of the long-term, value is created by our ability to extend our market leadership position in comprehensive genetic testing while building a powerful platform using variant interpretation and clinical insights, followed by new products in oncology care, pharmacogenomics, and an emerging data business. By integrating and connecting our portfolio of tests, information, decision supportproducts and workflow tools is designedservices, we are evolving from a one-patient, one-test business model to inform and empower healthcare providers everywhere and enable billions of people to understand and act on the most fundamental of health information that makes them unique. Integral to our mission is thatone where each patient owns and controls their data and can chooseinteraction provides multiple opportunities to apply that information to benefitdeliver solutions — for them, their families and others in the healthcare ecosystem. Applied broadly,This multiplying value proposition can translate directly to better patient outcomes, greater innovation, higher revenue, higher profitability, higher growth, and stronger returns. We are uniquely positioned to do this, informationnot simply because we think it makes sense, but also because patients will inform lifestyle and treatment decisions, improve outcomes, speed medical innovation and reduce costs among all global healthcare systems.demand it.
The paceOur goals for 2023 are to continue to expand the ways we serve patients and customers, to further unlock profitable growth, to strengthen our infrastructure, to invest in our most promising future bets and clinical evidence, and to do these while managing our cash. We will balance our focus on growth with an emphasis on long-term profitability and capital management to scale our business.
Finally, I can’t talk about the efforts of change has been astonishing,Invitae without highlighting the impact of the talented, versatile, and yet it is only accelerating. Please join us ashard–working employees who are Invitaens. It’s not easy going through a major realignment, and I am proud of how we launchfinished 2022 with a new genomic platformdetermination and grit that were impressive to witness. I am honored to be a part of this group, and I am optimistic about Invitae’s future. We are grateful to our customers and patients for healthcare, explore the full potential oftheir business and for their trust, and to our collective health and reap the rewards of truly personal healthstockholders for patients,their support. We look forward to reporting our partners, our company and society.continued success for many years to come.
INVITAE CORPORATION • 2023 Proxy Statement 1
You are cordially invited to attend the 20222023 Annual Meeting of Stockholders of Invitae Corporation, which will be held at 4:00 p.m., Pacific Time, on Monday, June 6, 2022. In light of the ongoing COVID-19 pandemic and to protect the health of our employees, stockholders and the community, the5, 2023. The Annual Meeting will be a completely virtual meeting of stockholders conducted via live audio webcast. You will be able to attend the Annual Meeting by visiting www.virtualshareholdermeeting. com/NVTA2022www.virtualshareholdermeeting.com/NVTA2023 and using the 16-digit control number included in your proxy materials. We currently expect to return to an in person meeting for our 2023 annual meeting of stockholders.
The formal notice of the Annual Meeting and the Proxy Statement have been made a part of this invitation.
Whether or not you plan to attend the Annual Meeting, it is important that your shares be represented and voted at the Annual Meeting. After reading the Proxy Statement, please promptly vote. Your shares cannot be voted unless you vote by Internet or telephone, vote as instructed by your broker, or vote your shares electronically at the Annual Meeting.Meeting.
We look forward to seeing you at the meeting.
Together in health,
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Kenneth D. Knight Chief Executive Officer |
Invitae Corporation
INVITAE CORPORATION• 20222023 Proxy Statement 12
To Be Held on Monday,
June 5, 2023
The Proxy Statement and Annual Report are available at |
To our stockholders:
Invitae Corporation will hold its 2023 Annual Meeting of Stockholders at 4:00 p.m., Pacific Time, on Monday, June 5, 2023. The Annual Meeting will be a completely virtual meeting of stockholders conducted via live audio webcast. You will be able to attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/NVTA2023 and using the 16-digit control number included in your proxy materials.
We are holding this Annual Meeting:
| • | to elect |
| • | to approve, the conversion of Notes and/or exercise of Warrants and the related change of control, as described in Proposal 2 (collectively, the “NYSE Proposal”); |
| • | to approve, on a non-binding advisory basis, the compensation paid by us to our named executive officers as disclosed in the attached Proxy Statement; |
| • | to ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the year ending December 31, 2023; and |
| •
| to transact such other business as may properly come before the Annual Meeting and any adjournments or postponements of the Annual Meeting.
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By OrderStockholders of record at the close of business on April 10, 2023 are entitled to notice of and to vote at the Annual Meeting and any adjournments or postponements of the Board of Directors,Annual Meeting.
Thomas R. BridaGeneral Counsel, Chief Compliance Officer and SecretarySan Francisco, CaliforniaApril 21, 2022
By Order of the Board of Directors,
Thomas R. Brida General Counsel, Chief Compliance Officer and Secretary San Francisco, California April 19, 2023 |
INVITAE CORPORATION• 20222023 Proxy Statement 23
Table of Contents
INVITAE CORPORATION• 20222023 Proxy Statement 34
Invitae Corporation 1400 16th Street San Francisco, California 94103 |
This Proxy Statement is being furnished to you in connection with the solicitation by the board of directors of Invitae Corporation, a Delaware corporation (“we,” “us,” “our,” “Invitae” or the “Company”), of proxies in the accompanying form to be used at the Annual Meeting of Stockholders of the Company to be held virtually on Monday, June 6, 20225, 2023 at 4:00 p.m., Pacific Time, and any adjournments or postponements thereof (the “Annual Meeting”).
TheWe intend to mail the Notice of Internet Availability of Proxy Materials (the “Notice”) is being mailedon or about April 19, 2023 to all stockholders of record entitled to vote at the Annual Meeting. We expect that this Proxy Statement and the other proxy materials will be available to stockholders on or about April 21, 2022.25, 2023.
Please promptly vote by Internet or telephone, or by following the instructions provided by your broker, bank or nominee, so that your shares can be represented at the Annual Meeting.
| YOU MAY VOTE IN ONE OF THE FOLLOWING WAYS: | 
INTERNET | 
TELEPHONE | 
MAIL |  | ||||
AT THE VIRTUAL MEETING | ||||||||
Visit www.virtualshareholdermeeting.com/ NVTA2023 and use the 16-digit control number included in your proxy materials |
INVITAE CORPORATION• 20222023 Proxy Statement 45
Our amended and restated bylaws (“Bylaws”) provide that our board of directors shall consist of such number of directors as the board of directors may from time to time determine. Our board of directors currently consists of sixeight directors. The authorized number of directors may be changed by resolution of our board of directors. Vacancies on our board of directors can be filled by resolution of our board. Our board of directors is divided into three classes, each serving staggered, three-year terms:
| • | Our Class I directors are Geoffrey S. Crouse, |
| • | Our Class II directors are Kimber D. Lockhart, |
| • | Our Class III directors are Eric Aguiar and |
TwoThree Class IIII directors will be elected at the Annual Meeting to serve until the annual meeting of stockholders to be held in 20252026 or until their successors are duly elected and qualified, with the other classes of directors continuing to serve for the remainder of their respective terms. The nominees receiving the highest number of affirmative votes will be elected as the Class IIII directors. The nominating and governance committee of the board has recommended, and our board of directors has designated, Eric Aguiar, M.D.Geoffrey S. Crouse, Christine M. Gorjanc and Sean E. George, Ph.D.Kenneth D. Knight as the nominees for Class IIII director to serve until the 20252026 annual meeting of stockholders, and each has indicated to us that hethey will be able to serve. If one or bothany of the nominees are unable or decline to serve as a director at the time of the Annual Meeting, an event that we do not currently anticipate, proxies will be voted for any nominees designated by our board of directors, taking into account any recommendations of the nominating and governance committee, to fill such vacancy.
Certain biographical information and other information regarding the Class IIII nominees and the other members of our board of directors as of April 1, 20222023 are set forth below:
| • | Director Independence. | |
| • | Director Diversity. 50% of our directors identify as | |
| • | Director Tenure. | |
| • | Director Age. | |
| • | Director Skills. Our directors have |
INVITAE CORPORATION• 20222023 Proxy Statement 56
The following table presents independence, tenure, skills, diversity attributes, age and committee assignments for our directors.
| Aguiar | Crouse | Gorjanc | Knight | Lockhart | Nayak | Osborne | Scott | |||||||||||
| Director Class | III | I | I | I | II | II | II | III | ||||||||||
| Independence |  | | | | | | | 88% | ||||||||||
| Tenure | ||||||||||||||||||
| Invitae board tenure (consecutive years) | 12 | 11 | 7 | 0 | 2 | 4 | 0 | 0 | 4.5 | |||||||||
| Invitae board tenure (total years) | 12 | 11 | 7 | 0 | 2 | 4 | 0 | 7 | 5.4 | |||||||||
| Skills | ||||||||||||||||||
| senior executive leadership | | | | | | | | | 100% | |||||||||
| finance and accounting expertise | | | | 38% | ||||||||||||||
| biotechnology / medical | | | | | | 63% | ||||||||||||
| growth / operations | | | | | | | | | 100% | |||||||||
| sales and marketing | | | | 38% | ||||||||||||||
| technology | | | | | | | 75% | |||||||||||
| cybersecurity / data privacy | | 13% | ||||||||||||||||
| business development / M&A | | | | | | 63% | ||||||||||||
| executive compensation and human capital management | | | | | | 63% | ||||||||||||
| global expertise | | | | | | | | 75% | ||||||||||
| corporate governance | | | | 25% | ||||||||||||||
| risk oversight | | | | 38% | ||||||||||||||
| public company board service | | | | | | | | 88% | ||||||||||
| environmental sustainability | | 13% | ||||||||||||||||
| Diversity | ||||||||||||||||||
| Gender Diversity | | | | 38% | ||||||||||||||
| Racial/Ethnic Diversity | | | | | 50% | |||||||||||||
| Age | 61 | 52 | 66 | 62 | 36 | 59 | 63 | 65 | 58 | |||||||||
| Committees | ||||||||||||||||||
 = Member;  = Chair | ||||||||||||||||||
| Audit | | | | | ||||||||||||||
| Compensation | | | | |||||||||||||||
| Nominating and Governance | | | |
INVITAE CORPORATION • 2023 Proxy Statement 7
Age:
INDEPENDENT
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INVITAE CORPORATION • 2022 Proxy Statement 6
Other Directors:
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| GEOFFREY S. CROUSE
Since July 2017, Mr. Crouse has served as Chief Executive Officer of |
Age: 66
INDEPENDENT Committees: • Audit (Chair) • Compensation | CHRISTINE M. GORJANC Ms. Gorjanc is an experienced financial executive with expertise gained through service as a chief financial officer as well as working in multinational public companies. Ms. Gorjanc served as the Chief Financial Officer of Arlo Technologies, Inc. (NYSE: Arlo), a home automation company, from August 2018 to June 2020. She previously served as the Chief Financial Officer of Netgear, Inc. (Nasdaq: NTGR), a provider of networking products and services, from January 2008 to August 2018, where she also served as Chief Accounting Officer from December 2006 to January 2008 and Vice President, Finance from November 2005 to December 2006. From September 1996 through November 2005, Ms. Gorjanc served as Vice President, Controller, Treasurer and Assistant Secretary for Aspect Communications Corporation, a provider of workforce and customer management solutions. From October 1988 through September 1996, she served as the Manager of Tax for Tandem Computers, Inc., a provider of fault-tolerant computer systems. Prior to that, Ms. Gorjanc served in management positions at Xidex Corporation, a manufacturer of storage devices, and spent eight years in public accounting with a number of public accounting firms. Ms. Gorjanc joined the board of Shapeways Holdings, Inc., a leader in the fast-growing digital manufacturing industry, in March 2023. Since May 2019, Ms. Gorjanc has served as a director of Juniper Networks, Inc. (NYSE: JNPR), a leader in secure AI driven networks, and from March 2021 to October 2022, Ms. Gorjanc served as a director of Zymergen Inc. (Nasdaq: ZY), a biotechnology company. Ms. Gorjanc holds a BA in accounting from the University of Texas at El Paso and an MS in taxation from Golden Gate University. In April 2022, Ms. Gorjanc achieved NACD Directorship Certified status (National Association of Corporate Directors). We believe that Ms. Gorjanc is qualified to serve on our board of directors due to her extensive experience in the technology industry and her management and financial experience. |
Age: 62 DirectorSince: 2022 | KENNETH D. KNIGHT Mr. Knight has served as our Chief Executive Officer since July 2022 and as our Chief Operating Officer from June 2020 to July 2022. Prior to joining the Company, Mr. Knight most recently served as vice president of transportation services at Amazon. com, Inc. (Nasdaq: AMZN), a multinational and diversified technology company, from December 2019 to June 2020, and as Vice President of Amazon’s Global Delivery Services, Fulfillment Operations and Human Resources from April 2016 to December 2019. Prior to his time at Amazon, from 2012 to March 2016, Mr. Knight served as General Manager of Material Handling and Underground Business Division at Caterpillar Inc., a manufacturer of machinery and equipment. Prior to that, Mr. Knight served in various capacities at General Motors Company (NYSE: GM), a vehicle manufacturer, for 27 years, including as Executive Director of Global Manufacturing Engineering and as Manufacturing General Manager. Since June 2021, Mr. Knight has served as a director and a member of the audit and finance committee of Simpson Manufacturing Co., Inc. (NYSE: SSD), a construction product manufacturer. Mr. Knight holds a BS in Electrical Engineering from the Georgia Institute of Technology and an MBA from the Massachusetts Institute of Technology. We believe that Mr. Knight’s business experience and his understanding of our business given his current role as Chief Executive Officer qualify him to serve on our board of directors. |
 | THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE ELECTION OF THE CLASS I NOMINEES SET FORTH ABOVE AS DIRECTORS OF THE COMPANY. |
INVITAE CORPORATION• 20222023 Proxy Statement 78
Age: 61
INDEPENDENT Committees: • •Nominating and Governance (Chair) | ERIC AGUIAR, MD Since January 2016, Dr. Aguiar has been a partner at Aisling Capital, an investment firm specializing in products, technologies, and global businesses that advance health. Prior to Aisling Capital, from October 2007 to December 2015, he was a partner at Thomas, McNerney & Partners, a healthcare venture capital and growth equity firm. From 2001 to 2007, Dr. Aguiar was a Managing Director of HealthCare Ventures, a healthcare focused venture capital firm. Dr. Aguiar was Chief Executive Officer and a director of Genovo, Inc., a biopharmaceutical company focused on gene delivery and gene regulation, from 1998 to 2000. Since December 2020, he has served as a director of Biomea Fusion (Nasdaq: BMEA), Inc., a preclinical-stage biopharmaceutical company. Since 2019, he has served as a director of BridgeBio Pharma, Inc. (Nasdaq: BBIO), a commercial-stage biopharmaceutical company. Dr. Aguiar previously served as a director of Eidos Therapeutics, Inc. (formerly Nasdaq: EIDX) in addition to Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN) and Amarin Pharmaceuticals (Nasdaq: AMRN), each a public biopharmaceutical company, as well as on the boards of directors of numerous private companies including companies in the life sciences industry. Since September 2021, Dr. Aguiar has served as a director of Garuda Therapeutics, a company focused on developing blood stem cell therapies. He is a member of the Council on Foreign Relations. Dr. Aguiar received an MD with honors from Harvard Medical School and a BA in Arts and Sciences from Cornell University. Dr. Aguiar was also a Luce Fellow and is a Chartered Financial Analyst. We believe that Dr. Aguiar is qualified to serve on our board of directors due to his extensive experience in the life sciences field, his experience on various public company boards, and his management and financial experience with life sciences companies. |
Age 36 INDEPENDENT Committees: • Audit • Nominating and Governance | KIMBER D. LOCKHART Ms. Lockhart currently serves on the boards of private and public companies, including as a director of Beam |
Age 59 INDEPENDENT Committees: • Nominating and Governance | CHITRA NAYAK Ms. Nayak serves as the ESG lead of our board of directors and is a public and private company board director for several businesses and an advisor to technology startups and venture firms 1414 Ventures & Plum Alley. From January 2019 to May 2021, she served as an adjunct faculty member at California State University’s MBA program. Ms. Nayak served as the Chief Operating Officer of Comfy, Inc., a real-estate technology company in the machine learning and IoT space, from February 2017 to June 2018, when it was acquired by Siemens, and prior to that, the Chief Operating Officer of Funding Circle Ltd., an online peer-to-peer lending marketplace, from February 2015 to May 2016. Prior to joining Funding Circle, Ms. Nayak worked at Salesforce, Inc., a cloud computing company, for eight years, serving in a variety of roles including Chief Operating Officer of Platform from February 2013 to January 2015, Senior Vice President of Global Sales Development from February 2008 to January 2013 and Vice President of Marketing Strategy & Operations from February 2007 to January 2008. From 2004 to 2006, Ms. Nayak served as Vice President, Membership Products for California State Automobile Association, a provider of automobile insurance. From 1999 to 2003, Ms. Nayak served as Vice President, Strategy & Operations of Charles Schwab Corporation, an investment and brokerage firm. Prior to that, Ms. Nayak spent six years with the Boston Consulting Group and four years with a number of environmental engineering consulting firms. Since March 2021, Ms. Nayak has served as a director of Infosys Limited (NYSE: INFY), an information technology company, and as a director of Forward Air Corporation (Nasdaq: FWRD). From November 2020 until its acquisition by TELUS Corporation in September 2022, she served as a director of LifeWorks Inc. (XTSE: LWRK). Ms. Nayak has served on the boards of directors of Intercom, a messaging platform company, since January 2020, and UrbanFootprint, a social impact data platform company, since March 2021. Ms. Nayak holds a BS in Engineering from the Indian Institute of Technology, an MS in Environmental Engineering from Cornell University, and an MBA from Harvard Business School (with honors). We believe that Ms. Nayak is qualified to serve on our board of directors due to her substantial experience scaling companies through high-growth phases as well as her background in operations and go-to-market strategies for complex businesses. |
INVITAE CORPORATION • 2023 Proxy Statement 9
Age: 63 INDEPENDENT Committees: • Audit | WILLIAM H. OSBORNE Mr. Osborne most recently served as Senior Vice President of Operations and Total Quality for Boeing Defense, Space & Security (BDS) at The Boeing Company (NYSE: BA), an aerospace company, from May 2020 to October 2022, and as Boeing’s Senior Vice President, Enterprise Operations, from May 2018 until April 2020. Prior to that, Mr. Osborne served in various capacities at Navistar, Inc., a producer of commercial and military trucks, including as Senior Vice President of Global Manufacturing and Quality from August 2013 to August 2018, as Senior Vice President of Custom Products from May 2011 to August 2013, and as Corporate Director from September 2009 to April 2012. Prior to his time at Navistar, from September 2008 to October 2010, Mr. Osborne served as President and Chief Executive Officer of Federal Signal Corporation (NYSE: FSS), a manufacturer of emergency vehicle equipment. Mr. Osborne has served on the board of directors at Quaker Chemical Corporation (NYSE: KWR), a chemical company, since December 2016. Mr. Osborne also serves on the board of directors of Armstrong World Industries, Inc. (NYSE: AWI), a designer and manufacturer of walls and ceilings, since July 2022. Mr. Osborne holds a BS in Mechanical Engineering from Kettering University, an MS in Engineering from Wayne State University, and an MBA from University of Chicago. We believe that Mr. Osborne is qualified to serve on our board of directors due to his considerable track record of operational leadership. |
Age: 65 Chair of the Board INDEPENDENT | RANDAL W. SCOTT, PHD Dr. Scott is a Co-Founder of the Company and served as Chair of the Board and Chief Executive Officer from 2012 to 2017 and Executive Chairman from 2017 to 2019. Prior to Invitae, Dr. Scott cofounded Genomic Health, Inc. (Nasdaq: GHDX), a genomic-based diagnostic testing company, where he served as the chairman and chief executive officer from 2000 to 2009 and the executive chairman from 2009 to 2012. Dr. Scott serves as a director and as a member of the audit committee of BridgeBio Pharma, Inc. (Nasdaq: BBIO), a commercial-stage biopharmaceutical company, and as a director, chair of the audit committee and member of the nominating and corporate governance committee of Talis Biomedical Corporation (Nasdaq: TLIS), a molecular diagnostic company. He also serves on the boards of directors of and/or as an advisor to several private companies in the life sciences/biotech industry. Dr. Scott holds a BS in Chemistry from Emporia State University and a PhD in Biochemistry from the University of Kansas. We believe that Dr. Scott is qualified to serve on our board of directors due to his years of experience in the life sciences industry and his extensive executive leadership, management and board experience at public companies, and as our former Chief Executive Officer. |
Our board of directors nominates directors whose term is scheduled to expire at the next annual meeting of stockholders and elects new directors to fill vacancies when they arise. Our nominating and governance committee has the responsibility to identify, evaluate, recruit and recommend qualified candidates to the board for nomination or election.
Our board of directors strives to find directors who are experienced and dedicated individuals with diverse backgrounds, perspectives and skills. Our Corporate Governance Guidelines contain membership criteria that call for candidates to be selected for their character, judgment, diversity of backgrounds, age, gender, ethnicity and professional experience, , business acumen and ability to act on behalf of all stockholders. In addition, we expect each director to be committed to enhancing stockholder value and to have sufficient time to effectively carry out his or her duties as a director. Our nominating and governance committee also seeks to ensure that a majority of our directors are independent under the rules of the New York Stock Exchange (the “NYSE”) and that one or more of our directors is an “audit committee financial expert” under the rules of the Securities and Exchange Commission (the “SEC”).
The nominating and governance committee believes it appropriate for our President and Chief Executive Officer (“CEO”) to participate as a member of our board of directors.
Prior to our annual meeting of stockholders, our nominating and governance committee identifies director nominees first by evaluating the current directors whose terms will expire at the annual meeting and who are willing to continue in service. The candidates are evaluated based on the criteria described above, the candidate’s prior service as a director, and the needs of the board of directors for any particular talents and experience. If a director no longer wishes to continue in service, if the nominating and governance committee decides not to re-nominaterenominate a director, or if a vacancy is created on the board of directors because of a resignation or an increase in the size of the board or other event, then the committee will consider whether to replace the director or to decrease the size of the board. If the decision is to replace a director, the nominating and
INVITAE CORPORATION • 2023 Proxy Statement 10
governance committee will consider various candidates for board membership, including those suggested by committee members, by other board members, a director search firm engaged by the committee or our stockholders. Prospective nominees are evaluated by the nominating and governance committee based on the membership criteria described above and set forth in our Corporate Governance Guidelines .Guidelines. The nominating and governance committee will consider candidates recommended by stockholders. A stockholder who wishes to suggest a prospective nominee for our board of directors should notify the Secretary of the Company or any member of the nominating and governance committee in writing with any supporting material the stockholder considers appropriate.
INVITAE CORPORATION • 2022 Proxy Statement 8
Our board of directors determined that Eric Aguiar, Geoffrey S. Crouse, Christine M. Gorjanc, Kimber D. Lockhart, and Chitra Nayak, William H. Osborne and Randal W. Scott are “independent directors” as defined under the rules of the NYSE. There are no family relationships among any of our directors or executive officers.
The members of our compensation committee during 20212022 were Geoffrey S. Crouse, Dr. Eric Aguiar and Christine M. Gorjanc. No member of our compensation committee in 20212022 was at any time during 20212022 or at any other time an officer or employee of ours. None of our executive officers currently serve, or has served during the last completed fiscal year, on the compensation committee or board of directors of any other entity that has one or more executive officers serving as a member of our board of directors or compensation committee.
Our board of directors held 25twenty meetings during 2021.2022. Each director attended at least 75% of the aggregate meetings held by our board of directors and the committees on which such director served. We do not have a policy that requires the attendance of directors at the Annual Meeting.our annual meetings of stockholders. Five of our directors attended the 20212022 annual meeting of stockholders.
During meetings of our board of directors, our independent directors meet in an executive session without management or management directors present. The purpose of these executive sessions is to promote open and candid discussion among the non-management directors. Dr. Eric Aguiar, our independent Chair of the Board since January 2021, presides over the executive sessions of the independent directors. Our board of directors welcomes questions or comments about our Company and our operations. If you wish to communicate with our board of directors, including our independent directors, you may send your communication in writing to: Secretary, Invitae Corporation, 1400 16th Street, San Francisco, California 94103. You must include your name and address in the written communication and indicate whether you are a stockholder or interested party. The Secretary will review any communication received from a stockholder or interested party, and all material communications will be forwarded to the appropriate director or directors or committee of our board of directors based on the subject matter.
We have established an audit committee, compensation committee and nominating and governance committee, each of which operate under a charter that has been approved by our board of directors. We believe that the composition of these committees meets the criteria for independence under, and the functioning of these committees complies with the applicable requirements of, the Sarbanes-Oxley Act, and the current rules and regulations of the SEC and the NYSE. We intend to comply with future requirements as they become applicable to us. Each committee has the composition and responsibilities described below.
INVITAE CORPORATION• 20222023 Proxy Statement 911
MEMBERS: • Christine M. Gorjanc (Chair) • Geoffrey S. Crouse • Kimber D. Lockhart • William H. Osborne NUMBER OF MEETINGS | FUNCTIONS: Our audit committee assists our board of directors in fulfilling its legal and fiduciary obligations in matters involving our accounting, auditing, financial reporting, internal control, internal audit, risk and cybersecurity oversight and legal compliance functions, and is directly responsible for the approval of the services performed by our independent registered public accounting firm and reviewing of their reports regarding our accounting practices and systems of internal accounting control. Our audit committee also oversees the audit efforts of our independent registered public accounting firm and takes actions as it deems necessary to satisfy itself that such firm is independent of management. Our audit committee is also responsible for monitoring the integrity of our consolidated financial statements and our compliance with legal and regulatory requirements as they relate to financial statements or accounting matters. Our board of directors has determined that each of Ms. Gorjanc and Mr. Crouse is an audit committee financial expert, as defined by the rules promulgated by the SEC, and has the requisite financial sophistication as defined under the applicable rules and regulations of the NYSE. |
Compensation Committee
MEMBERS: • Geoffrey S. Crouse (Chair) • Eric Aguiar, • Christine M. Gorjanc NUMBER OF MEETINGS | FUNCTIONS: Our compensation committee assists our board of directors in meeting its responsibilities with regard to oversight and determination of executive compensation and assesses whether our compensation structure establishes appropriate incentives for officers and employees. Our compensation committee reviews and makes recommendations to our board of directors with respect to our major compensation plans, policies and programs. In addition, our compensation committee reviews and makes recommendations for approval by the independent members of our board of directors regarding the compensation for our executive officers, establishes and modifies the terms and conditions of employment of our executive officers and administers our stock option plans. The compensation committee has the authority, in its sole discretion, to select, retain, or obtain the advice of, any adviser to assist in the performance of its duties, but only after taking into consideration all factors relevant to the adviser’s independence from management.
Our board of directors has established a Special Stock Incentive Plan Committee, the members of which are our |
MEMBERS: • Eric Aguiar, • Kimber D. Lockhart • Chitra Nayak NUMBER OF MEETINGS | FUNCTIONS: Our nominating and governance committee is responsible for making recommendations to our board of directors regarding candidates for directorships and the size and composition of the board of directors. In addition, our nominating and governance committee is responsible for overseeing our Corporate Governance Guidelines, and reporting and making recommendations to the board of directors concerning corporate governance matters. Our nominating and governance committee also reviews the overall adequacy of our Corporate Social Responsibility and Environmental, Social and Governance strategy, initiatives and policies, including communications with employees, investors and other stakeholders. For ESG matters, Ms. Nayak serves as the liaison between our nominating and governance committee and our |
INVITAE CORPORATION• 20222023 Proxy Statement 1012
Our board of directors continuously evaluates its leadership structure, taking into account the evolving needs of the business and the interests of our stockholders. Our board of directors currently believes that it is in the best interests of the Company and its stockholders to separate the Chair of the Board and Chief Executive Officer roles and for our Chair to be independent. Since January 2021,July 2022, Dr. Aguiar, our longest serving independent director,Scott has served as our independent Chair of the Board. Our board of directors believes that our current structure, with an independent Chair, gives our board of directors a strong leadership and corporate governance structure that best serves the needs of the Company and its stockholders.
The Chair of the Board:
| • | presides at all meetings of our board of directors, and has the authority to call |
| • | approves board meeting agenda items and schedules; |
| • | helps facilitate communication between senior management and the independent directors; |
| • | works with committee chairs to oversee coordinated coverage of board responsibilities; |
| • | serves as an advisor to the Chief Executive Officer; |
| • | presides over all meetings of stockholders; and |
| • | participates and provides leadership on Chief Executive Officer performance evaluation and succession planning. |
Our lead independent director works with the Chair of the Board and our Chief Executive Officer on the board meeting agenda items and schedules, and serves in place of the Chair of the Board in the Chair’s absence.
Our board of directors is responsible for overseeing the overall risk management process at the Company. The responsibility for managing risk rests with executive management while the audit committees of our board of directors and our board of directors as a whole participate in the oversight process. Our board of directors’ risk oversight process builds upon management’s risk assessment and mitigation processes, which include reviews of long-term strategic and operational planning, executive development and evaluation, regulatory and legal compliance, environmental, social and governance initiatives, cybersecurity, COVID-19, financial reporting, internal risk management and internal controls.
Our Bylaws provide that if a majority of the votes cast for a director are marked “against” or “withheld” in an uncontested election, the director must promptly tender his or her irrevocable resignation for our board of directors’ consideration. In addition, our Corporate Governance Guidelines provide that the board shall nominate or elect as a director only persons who agree to tender, promptly following his or her election or re-election to the board, an irrevocable resignation that will be effective upon (i) the failure of the candidate to receive the required vote at the next annual meeting at which he or she faces re-election and (ii) the acceptance by the board of such resignation.
Our Bylaws provide a proxy access provision stating that stockholders who meet the requirements set forth in our Bylaws may under certain circumstances include a specified number of director nominees in our proxy materials. Under the provision, eligible stockholders, or a group of up to 20 stockholders, owning at least 3% of our outstanding shares of common stock continuously for at least three years, may nominate and include in our annual meeting proxy materials a limited number of director nominees constituting up to the greater of (i) two directors or (ii) 20% of the board (rounded down to the nearest whole number), subject to certain limitations and provided that the stockholders and nominees satisfy the requirements specified in our Bylaws.
INVITAE CORPORATION • 2023 Proxy Statement 13
Our purpose and values guide our aim to improve healthcare for all, uphold our social responsibility, exercise environmental stewardship and govern with trust and transparency throughout our business.
Our board of directors, has delegatedas a whole and through its standing committees, works with our senior executive leadership team to oversee ESG issues. Our business functions drive management accountability for a range of ESG areas designed to maximize our impacts, drive better business performance and create long-term value for our stakeholders. While the entire board engages in corporate ESG matters, the nominating and governance committee, per its charter, has oversight responsibility offor our company-wide Corporate Social Responsibility (CSR)corporate social responsibility (“CSR”) and Environmental, Social and Governance (ESG)ESG strategy, initiatives and policies. Chitra Nayak serves on the nominating and governance committee and acts as the liaison between our board ourand management team and our Chief Sustainability Officer on these matters.
The responsibility for implementingOur CEO appointed our chief sustainability officer to oversee our day-to-day sustainability program and lead our ESG strategy and the day-to-day management has been delegated by our board of directors to the Chief Sustainability Officer, who leadsefforts including the ESG Steering Committee. The ESG Steering Committee, asteering committee. This committee is composed of senior cross-functional group comprising leaders from ESG, people & culture, facilities,medical affairs, human resources, finance, legal, medical affairs, operations, global supply, employee health & safety, productfacilities and tech, external affairs, communicationsothers to champion our ESG program and commercial, guides and implementsguide our multiyear efforts to improve ESG strategy. The ESG team provides updates tocapabilities across our board quarterly.business.
INVITAE CORPORATION • 2022 Proxy Statement 11
Additional information about our ESG activities is available in our ESG Report from March 2022, which, althoughReport. Although not incorporated by reference into this Proxy Statement, our ESG Report is available at our website at www.invitae.com/social-responsibility.
Our ESG approach reflects the passion in our work to reach more patients, support our clinicians, and lead in the advancement of the science of genetics. We developed core set of tenets representsto represent the principles that direct our actions, enable us to make decisions atguide our decision-making across all levels of the organization, and form the foundation of our sustainability efforts.
| 1. | Healthcare for | |
| 2. | ||
| 3. | Environmental | |
| 4. | Governance: We ensure that our governance structure and policies implement ethical, transparent and accountable business practices to ensure corporate performance and value. |
We understand that engaging with our internal and external stakeholders is critical for our long-term business success. We proactively engage them in continuous dialogue regarding our business and sustainability efforts through open discussion, collaboration and transparent disclosure. We apply stakeholders’ valued perspectives to inform, prioritize and continually improve our ESG strategy and advance our social and environmental initiatives.
We provide affordable testing, integrated health information, digital solutions and data services to shape genomic medicine and support patients through all stages of life. As a result, we believe healthcare relies less on trial and error and more on fact-based analysis of biology and medical risks using genomic information.
| • | Our 2022 efforts included a focus on improving patient outcomes and the science of genetics, broadening access through affordability, expanding to underserved populations, and driving access through patient advocacy. |
| • | We released a Data Use Transparency and |
| • | We tirelessly advocate for expanded access to genetic testing. We believe our |
Social
Our commitment to our people and communities is intrinsically linked to our overall mission to improve people’s healthcare. We advanced several initiatives in 2021are dedicated to expand access to and affordabilityfostering a culture of healthcare for a wider range of patients and to further our internal efforts on diversity, equity and inclusion. inclusion to positively impact our people and business.
Our medical affairsrelationships with our employees and other groups across the company focused on accessstakeholders in our value chain fall within our social responsibility. For our employees, we strive to affordable healthcare, equity in genetic testing, supporting genetic educationcreate an innovative and diversity insupportive workplace. We also aim to uphold the genomics workforce,value of our core ESG tenets via our safety protocols, quality management systems and enabling patients to power research and better clinical outcomes. Internally,vendor compliance requirements.
In 2022, we strengthened our programs in an effort to ensure equitable representation, engagement and advancement of all employees, especially those from historically underserved and disenfranchised communities, and the safety of our employees during COVID.employees.
| • | Our diversity, equity, and inclusion mission is to engage, develop and retain talent by fostering community, providing education and support and advancing inclusive research and health equity globally. We have a dedicated team focused on driving this effort. | |
| • | As of December 31, | |
| • | Our workforce is approximately |
INVITAE CORPORATION • 2023 Proxy Statement 14
| • | Invitae believes that employee engagement is directly connected to purpose, and through our |
| • | We maintained ongoing employee engagement through quarterly team surveys and monthly pulse surveys. |
| • |
Environment
During 2021, we took steps to strengthenSustainability is part of our DNA, and our environmental commitment. Our effectiveness in executing our environmental objectives begins with understandingstewardship is a serious endeavor. We recognize climate change has a direct impact on human health and well-being. We work to examine and minimize our environmental impact and carbon footprint,decrease our emissions footprint. Our efforts include integrating energy-efficient technologies and we began with assessing our Scope 1 and Scope 2 data.advancing eco-friendly products.
| • | Since 2019, our team has tracked energy use, water consumption and waste data to eventually achieve carbon neutrality. We continue to operationalize data collection for Scope 1 and Scope 2 emissions and ready ourselves for forthcoming regulatory reporting requirements inclusive of Scope 3. | |
| • | Since the establishment of our Green Ambassadors Program (GAP) in 2021, we have continued to operationalize our environmental sustainability-related practices. The role of GAP is to advance our environmental sustainability programs (including carbon tracking) and encourage the use of best practices across sites. | |
| • | We realize our effectiveness in executing our objectives begins with understanding our environmental impact and carbon footprint. As a result, we engaged a third-party expert to complete an in-depth analysis of our 2020, 2021 and | |
INVITAE CORPORATION • 2022 Proxy Statement 12
Governance
In 2021, plays a critical role in driving our ESG goals. Our board leadership — combined with how we strengthened our governance efforts by reporting on our diversity, enhancing ourmanage risk, implement ethics compliance, and ensure privacy and data security programs, progressing on ISO certifications— is crucial for our long-term success. Our board continuously evaluates its leadership structure and quality management programs,considers the evolving needs of the business and adopting several new programs related tointerests of our supply chain.stockholders.
| • | Our board of directors reflects diversity in experience, skills, race, ethnicity, age and gender. As of | |
| • | We have ethics and compliance policies and programs, including a Code of Business Conduct and Ethics that applies to each of our directors, officers and employees, and training on these policies, with compliance tracked and overseen by our Chief Compliance Officer. | |
| • | In January 2022, we adopted a Supplier Code of Conduct, which details our expectations for our suppliers and their subcontractors to comply with applicable laws and to operate their businesses in an ethical and sustainable manner. | |
| • | We concurrently instituted a Human Rights Policy, which outlines the fundamental rights, freedoms and standards of treatment to which we believe all people are entitled. These rights include respect for labor rights, treating all people with dignity and respect, enabling a healthy and safe work environment, promoting ethical behavior and respecting privacy. We recognize that we are part of the communities in which we operate, and as part of our mission, we believe respect for human rights is integral to our business. | |
| • | Four Invitae core laboratories (San Francisco, Irvine, Metropark and Sydney, Australia) achieved accreditation by the International Organization for Standardization (ISO) for Clinical Laboratories ISO 15189. This distinction validates our dedication to continuous quality improvement for patients and ability to operate a resilient laboratory organization. | |
| • | ||
| • | Ensuring that people own and control their genetic data has been one of our core principles from inception. We are committed to the privacy and security of all protected health information (PHI) we create, receive, use, disclose and transmit. We allow users to access, rectify and delete certain of their data on our platform. | |
| • | Our privacy practices are explained within our HIPAA Notice of Privacy Practices and | |
| • | We |
INVITAE CORPORATION • 2023 Proxy Statement 15
It is our policy that all employees, officers and directors must avoid any activity that is or has the appearance of conflicting with the interests of the Company. This policy is included in our Code of Business Conduct and Ethics as discussed below. Additionally, we conduct a review of all related party transactions for potential conflict of interest situations on an ongoing basis and all such transactions relating to executive officers and directors must be approved by our audit committee, as discussed below.
Our board of directors has adopted written Corporate Governance Guidelines to ensure that the board will have the necessary authority and practices in place to review and evaluate our business operations as needed and to make decisions that are independent of our management. The guidelines are also intended to align the interests of directors and management with those of our stockholders. The Corporate Governance Guidelines set forth the practices the board intends to follow with respect to board composition and selection, board meetings and involvement of senior management, Chief Executive Officer performance evaluations and succession planning, and board committees and compensation. The nominating and governance committee assists our board of directors in implementing and adhering to the Corporate Governance Guidelines. The Corporate Governance Guidelines are reviewed at least annually by the nominating and governance committee, and changes are recommended to our board of directors as warranted.
Code of Business Conduct and Ethics
We believe that our corporate governance initiatives comply with the Sarbanes-Oxley Act and the rules and regulations of the SEC adopted thereunder. In addition, we believe our corporate governance initiatives comply with the rules of the NYSE. Our board of directors will continue to evaluate our corporate governance principles and policies.
Our board of directors has adopted a Code of Business Conduct and Ethics that applies to each of our directors, officers and employees. The code addresses various topics, including:
| • | compliance with laws, rules and regulations; |
| • | interacting with healthcare professionals; |
| • | quality of products and services; |
| • | privacy and data security; |
| • | prohibiting bribery and corrupt payments; |
| • | transfers of value; |
| • | fair dealing; |
| • | environmental stewardship; |
| • | safe and healthy workplace; |
| • | open and respectful workplace; |
| • | policy against retaliation; |
| • | confidentiality; |
| • | insider trading; |
| • | communicating on behalf of the Company; |
| • | conflicts of interest; |
| • | corporate opportunities; |
| • | |
| protection and proper use of company assets; and | |
| • | record keeping. |
Our board of directors has also adopted a Code of Ethics for Senior Financial Officers applicable to our Chief Executive Officer and Chief Financial Officer as well as other key management employees addressing ethical behavior, compliance with law and reporting of material information. The Code of Business Conduct and Ethics and the Code of Ethics for Senior Financial Officers can only be amended by the approval of a majority of our board of directors. Any waiver to the Code of Business Conduct and Ethics for an executive officer or director or any waiver of the Code of Ethics for Senior Financial Officers may only be granted by our board of directors or a committee thereof and must be timely disclosed as required by applicable law. We have implemented whistleblower procedures that establish formal protocols for receiving and handling complaints from employees. Any concerns regarding accounting or auditing matters reported under these procedures will be communicated promptly to our audit committee.
To date, there have been no waivers under our Code of Business Conduct and Ethics or Code of Ethics for Senior Financial Officers. We intend to disclose future amendments to certain provisions of these codes or waivers of such codes granted to executive officers and directors on our website at ir.invitae.com within four business days following the date of such amendment or waiver.
Our Corporate Governance Guidelines, Code of Business Conduct and Ethics, Code of Ethics for Senior Financial Officers, charters for each of the audit, compensation and nominating and governance committees and other corporate governance documents, are posted on the investor relations section of our website at ir.invitae.com under the heading “Governance — Governance“Leadership —Governance documents.” In addition, stockholders may obtain a printed copy of these documents by writing to Secretary, Invitae Corporation, 1400 16th Street, San Francisco, California 94103.
INVITAE CORPORATION • 2023 Proxy Statement 16
In addition to the compensation arrangements of our directors and named executive officers discussed elsewhere in this Proxy Statement or disclosed below, there were no transactions since January 1, 20212022 to which we have been or will be a party, and in which the amount involved exceeded or will exceed $120,000 and in which any of our directors, executive officers, beneficial holders of more than 5% of our capital stock, or entities affiliated with, or immediate family members of, any of the foregoing, had or will have a direct or indirect material interest.
In 2021, we paid $102,400the Company invested $1,000,000 in membership feesSeries B Preferred Stock of Genomic Life, Inc., a company focused on accelerating access to affordable and $211,485 in medical claims inengaging genomics-based, proactive health solutions, for which Dr. Scott serves on the ordinary courseboard of business to One Medical. Ms. Lockhart, our director, serveddirectors (including as Chief Technology Officer of One Medical until June 2021.executive co-chair) and is a significant stockholder.
We have entered into indemnification agreements with our directors and executive officers. These agreements require us to indemnify these individuals to the fullest extent permitted under Delaware law against liabilities that may arise by reason of their service to us, and to advance expenses incurred as a result of any proceeding against them as to which they could be indemnified.
We have adopted a written policy that our executive officers, directors, holders of more than 5% of any class of our voting securities, and any member of the immediate family of and any entity affiliated with any of the foregoing persons, are not permitted to enter into a related party transaction with us without the prior consentreview and approval of our audit committee.committee in accordance with such policy. Any request for us to enter into a transaction with an executive officer, director, principal stockholder, or any of their immediate family members or affiliates, in which the amount involved exceeds $120,000 must first be presented to our audit committee for review, consideration and approval. In approving or rejecting any such proposal, our audit committee will approve only those transactions it determines are
INVITAE CORPORATION • 2022 Proxy Statement 14
fair to and in the best interests of the Company, after considering the relevant facts and circumstances available and deemed relevant to our audit committee, including, but not limited to, whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third party under the same or similar circumstances and the extent of the related party’s interest in the transaction.
INVITAE CORPORATION • 2023 Proxy Statement 17
Our director compensation is based on the recommendation of our independent compensation consultant as to what is market competitive and did not change for 2022. The following table shows certain information with respect to the compensation of our non-employee directors during the fiscal year ended December 31, 2021:2022, including the compensation paid to Dr. George in the role of a non-employee director:
| Name | Fees earned or paid in cash ($) | Stock awards ($) | Option awards ($) | (1) | All other compensation ($) | Total ($) | |||||
| Eric Aguiar, M.D. | 75,250 | 401,350 | 132,516 | — | 609,116 | ||||||
| Geoffrey S. Crouse | 55,000 | 296,650 | 98,825 | — | 450,475 | ||||||
| Christine M. Gorjanc | 60,000 | 296,650 | 98,825 | — | 455,475 | ||||||
| Kimber D. Lockhart | 42,500 | 296,650 | 98,825 | — | 437,975 | ||||||
| Chitra Nayak | 38,750 | 296,650 | 98,825 | — | 433,225 |
| Name | Fees earned or paid in cash ($) | Stock awards ($) | Option awards ($) | (1) | All other compensation ($) | Total ($) | |||||
| Eric Aguiar, MD | 106,019 | 226,548 | 76,030 | – | 408,597 | ||||||
| Geoffrey S. Crouse | 75,000 | 167,562 | 56,150 | – | 298,712 | ||||||
| Christine M. Gorjanc | 77,500 | 167,562 | 56,150 | – | 301,212 | ||||||
| Kimber D. Lockhart | 65,000 | 167,562 | 56,150 | – | 288,712 | ||||||
| Chitra Nayak | 55,000 | 167,562 | 56,150 | – | 278,712 | ||||||
| Randal W. Scott, PhD | 50,000 | 153,330 | 53,005 | – | 256,335 | ||||||
| Sean E. George, PhD(2) | 22,690 | 45,743 | 8,462 | – | 76,895 |
| (1) | Amounts represent the aggregate fair value of the option awards computed as of the grant date of each award in accordance with Financial Accounting Standards Board Accounting Standards Codification (“ASC”) Topic 718 |
| The following table sets forth the aggregate number of shares of common stock underlying stock and option awards outstanding on December 31, |
| Name | Number of shares | |
| Eric Aguiar, MD | ||
| Sean E. George, PhD | 52,784 |
| (2) | For his service on the Board following his transition from the CEO role through December 31, 2022, Dr. George received the following: (i) an RSU grant for 16,050 shares of common stock which vested in full on December 15, 2022, (ii) a nonqualified stock option for 8,050 shares of common stock, with an exercise price of $2.85 per, the closing stock price of our common stock on July 15, 2022, which also vested n full on December 15, 2022 and will remain exercisable until June 15, 2023 or, if earlier, any noncompliance by Dr. George with his obligations under the Transition and Separation Agreement, which was executed by Dr. George and the Company on July 17, 2022; and (iii) cash compensation of $12,500 per calendar quarter. The stock options are valued at $1.0512 per share, reflecting a grant date stock price of $2.85 and a Black-Scholes value of 36.88%. |
INVITAE CORPORATION • 2023 Proxy Statement 18
Employee directors do not receive any compensation for service as a member of our board of directors. We reimburse our non-employee directors for their reasonable out-of-pocket costs and travel expenses in connection with their attendance at board and committee meetings. Employee directors do not receive any compensation for service as a member of our board of directors.
Each non-employee director is entitled to receive annual cash compensation for their service on our board of directors, payable quarterly in arrears. Annual compensation is pro-rated for non-employee directors with less than 12 months of service. Unpaid retainers are payable in full for the current fiscal year in the event of a change in control of our Company during that fiscal year. The annual retainer for service on our board of directors was $50,000.
Each non-employee director who joins our board of directors receives a fixed dollar value of $600,000$400,000 of stock, 75% of which is in the form of restricted stock units (“RSUs”), with one quarter of the RSUs vesting on each of the first four anniversaries of the director’s appointment, subject to the director’s continuous service as a member of our board of directors, and 25% of which is in the form of stock options using the Black-Scholes option-pricing model, with one quarter of the shares subject to the option vesting on the first anniversary of the director’s appointment or election to our board of directors and 1/48th of the shares subject to the option vesting on a monthly basis over the following three years, subject to the director’s continuous service as a member of our board of directors. The exercise price of the options will be the fair market value on the date of grant. If still vesting, the RSUs and the options will accelerate in full upon a change in control of our Company.
Annual Equity Grants
Each non-employee director with at least 12 months of continuous service as of the date of each annual meeting of our stockholders is entitled to receive an annual award of a fixed dollar value of $425,000$200,000 of stock, 75% of which is in the form of RSUs vesting the following year and 25% of which is in the form of stock options using the Black-Scholes option-pricing model, vesting on a monthly basis over the following year. Directors with less than 12 months of continuous service as of such annual meeting are also entitled to receive such an award, but with the dollar value pro-rated to reflect their applicable portion of a full year of service. The exercise price of the options will be the fair market value on the date of grant. If still vesting, the RSUs and the options will accelerate in full upon a change in control of our Company.
The chairChair of the board of directorsBoard receives an annual fee of $50,000 in cash and an annual equity grant with a fixed dollar value of $150,000, 75% of which is in the form of RSUs vesting the following year and 25% of which is in the form of stock options using the Black-Scholes option-pricing model, vesting on a monthly basis over the following year. If still vesting, the RSUs and the options will accelerate in full upon a change in control of our Company. The lead independent director receives an annual fee of $25,000 in cash. In addition, Dr. Aguiar’s unvested equity granted with respect to his service as Chair of the Board continues to vest so long as he remains the lead independent director. The chair of the audit committee receives an annual fee of $20,000 and the non-chair members of the audit committee receive an annual fee of $10,000. The chair of the compensation committee receives an annual fee of $15,000 and the non-chair members of the compensation committee receive an annual fee of $7,500. The chair of the nominating and governance committee receives an annual fee of $10,000 and the non-chair members of the nominating and governance committee receive an annual fee of $5,000. The lead independent director, if applicable, receives an annual fee of $25,000.
INVITAE CORPORATION• 20222023 Proxy Statement 1619
The names of our executive officers and their ages as of April 1, 20222023 are as follows:
| Name | Age | Position | ||
| Yafei (Roxi) Wen | Chief Financial Officer | |||
| Thomas R. Brida | General Counsel, Chief Compliance Officer and Secretary | |||
| Robert L. Nussbaum, | Chief Medical Officer |
Certain biographical information of our executive officers, excluding that of Dr. George,Mr. Knight, are set forth below:
Yafei (Roxi) Wen has served as our Chief Financial Officer since June 2021. Prior to joining Invitae, from February 2019 to June 2021, she served as the Chief Financial Officer at Mozilla Corporation, an open-source software company, overseeing finance and accounting, mergers and acquisitions, business development, data and analytics, information technology and engineering operations, workplace resources and sustainability. Prior to that, Ms. Wen served as the Chief Financial Officer at Elo Touch Solutions, a touch screen systems and components company, from April 2014 to February 2019, and General Electric Critical Power, an electronics power technology company, from 2008 to 2013, following experience driving capital market and business finance efforts as finance manager at Medtronic, a leading medical technology company, from 2002 to 2008. Ms. Wen holds a Bachelor of Economics from Xiamen University, is a CFA charterholder and has an M.B.A.MBA from the University of Minnesota.
Thomas R. Brida has served as our General Counsel since January 2017, our Chief Compliance Officer since February 2019, and our Secretary since May 2019. Mr. Brida also served as our Deputy General Counsel from January 2016 to January 2017.
Prior to joining Invitae, he was Associate General Counsel at Bio-Rad Laboratories, a life science research and clinical diagnostics manufacturer, from January 2004 to January 2016. Mr. Brida holds a B.A.BA from Stanford University and a J.D.JD from the University of California, Berkeley School of Law.
Kenneth D. Knight has served as our Chief Operating Officer since June 2020. Prior to joining Invitae, Mr. Knight most recently served as Vice President of transportation services at Amazon. com, Inc., a multinational and diversified technology company, from December 2019 to June 2020, and as Vice President of Amazon’s global delivery services, fulfillment operations and human resources from April 2016 to December 2019. Prior to his time at Amazon, from 2012 to March 2016, Mr. Knight served as general manager of material handling and underground business division at Caterpillar Inc., a manufacturer of machinery and equipment. Prior to that, Mr. Knight served in various capacities at General Motors Company, a vehicle manufacturer, for 27 years, including as executive director of global manufacturing engineering and as manufacturing general manager. Since June 2021, Mr. Knight serves as a director, and a member of the audit and finance committee, of Simpson Manufacturing Co. Inc. (NYSE: SSD), a construction product manufacturer. Mr. Knight holds a B.S. in Electrical Engineering from the Georgia Institute of Technology and an M.B.A from the Massachusetts Institute of Technology.
Robert L. Nussbaum, M.D.MD has served as our Chief Medical Officer since August 2015. From April 2006 to August 2015, he was chief of the Division of Genomic Medicine at UCSF Health where he also held leadership roles in the Cancer Genetics and Prevention Program beginning in January 2009 and the Program in Cardiovascular Genetics beginning in July 2007. From April 2006 to August 2015, he served as a member of the UCSF Institute for Human Genetics. Prior to joining UCSF Health, Dr. Nussbaum was chief of the Genetic Disease Research Branch of the National Human Genome Research Institute, one of the National Institutes of Health, from 1994 to 2006. He is a member of the National Academy of Medicine and a fellow at the American Academy of Arts and Sciences. Dr. Nussbaum is a board-certified internist and medical geneticist who holds a B.S.BS in Applied Mathematics from Harvard College and an M.D.MD from Harvard Medical School in the Harvard-MIT joint program in Health Sciences and Technology. He completed his residency in internal medicine at Barnes-Jewish Hospital and a fellowship in medical genetics at the Baylor College of Medicine.
INVITAE CORPORATION • 2022 Proxy Statement 17
Robert F. Werner, 48, has served as our Chief Accounting and Principal Accounting Officer since May 2020. Prior to that, Mr. Werner served as our Corporate Controller sincefrom September 2017.2017 to May 2020. Prior to joining Invitae, from February 2015 to September 2017, Mr. Werner served as Vice President of Finance and Corporate Controller of Proteus Digital Health, Inc., a digital medicine pharmaceuticals company. Prior to that, Mr. Werner served as Corporate Controller and Principal Accounting Officer of CardioDx, Inc., a molecular diagnostics company, from March 2012 to February 2015. Mr. Werner is a Certified Public Accountant in California and started his career at Ernst & Young LLP. Mr. Werner holds a B.S.BS in Accounting and a Master of Accountancy in Professional Accounting from Brigham Young University’s Marriott School of Management.
INVITAE CORPORATION• 20222023 Proxy Statement 1820
Table of Contents
This section explains how our executive compensation program is designed and operates with respect to our named executive officers listed in the Summary Compensation Table below. Our named executive officers consist of individuals who served, during 2021,2022, as our principal executive officer, our principal financial officer and the threetwo most highly compensated executive officers (other than the principal executive officer and principal financial officer) who were serving as executive officers at the end of 2021, and a former executive officer.2022. The named executive officers in 20212022 were:
INVITAE CORPORATION• 20222023 Proxy Statement 1921
The objective of our executive compensation program is to ensure we meet our commitment to stakeholders, in the following order:
We believe we can build long-term stockholder value by executing on our mission to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Our goal isstrategy for long-term, profitable growth centers on seven key drivers of our business, which we believe work in conjunction to aggregatecreate a flywheel effect extending our leadership position in the world’s genetic tests into a single service with higher quality, faster turnaround time, and lower prices.new market we are building. Our executive compensation program takes into account the dynamic growth of our business and our focused execution on our core business model. Our executive compensation philosophy is focused on real pay delivery through the achievement of performance targets, which ultimately drives total stockholder return (“TSR”) and aligns our named executive officers with long-term stockholders.
In 2022, we announced a strategic realignment plan to stabilize our portfolio, focus on profitable growth and reduce cash burn. Our results in 2022 reflect the execution of these priorities. Looking into 2023, we will continue to work towards enabling an integrated, connected portfolio, generating profitable growth, and investing in our most promising future bets and clinical evidence. We will balance our focus on growth with an emphasis on long-term profitability and capital management to scale our business.
The following presents certain non-GAAP financial measures. A reconciliation to GAAP is presented in Annex A.
| Revenue breakdown – Q4 and FY’22 | |
 | |
| Note: | |
| * | May not sum due to rounding Drawings not to scale. |
INVITAE CORPORATION• 20222023 Proxy Statement 2022
Financial Summary and Compensation Highlights
Our results in 2021, which exceeded our outlook a year ago, underscore the strength of our unique model for engaging patients and physicians early, delivering new and efficient ways to interact and provide information to those patients and support their providers at every step along the way. The growth in testing during this period demonstrates the value of our differentiated strategy of expanding access to and use of genetic information for all patients as they plan for a healthier life. Looking into 2022, we are confident in our continued ability to execute and integrate new technologies to expand our menu, services and data platform as we enter into this next phase of our business model on our way to establishing genome management as the future of medicine.
The highlights for 2021 are set forth below.
Performance Highlights
| Cash burn1 trend2 | |
 | |
| 1. | Ongoing cash burn includes cash, cash equivalents, marketable securities, and restricted cash and excludes certain items. |
| 2. | Non-GAAP measures. See reconciliation for GAAP to non-GAAP in Annex A. |
| 3. | Cash items in Q3 ’22 outflow of $43.2 million related to restructuring-related cash payments and acquisition-related payments. |
| 4. | Cash items in Q4 ’22 outflow of $9.3 million related to realignment, $0.1 million acquisition-related payments, and an inflow of $44.5 million related to the selected assets sale of the RUO kitted solutions. |
| * | May not sum due to rounding. Drawings not to scale. |
| Portfolio growth | |
 | |
| * | |
INVITAE CORPORATION• 20222023 Proxy Statement 2123
2021
During 2021, weOn July 16, 2022, Mr. Knight succeeded Dr. George as CEO and Dr. George entered into a Transition and Separation Agreement summarized in the “Transition and Separation Agreement” section below. Dr. George did not changereceive an equity grant for 2022. He received cash severance and a COBRA payment pursuant to his Change in Control Agreement and, subject to satisfaction of certain restrictive covenants, a pro rata, 69.9% of target cash bonus payment of $582,637. Mr. Knight’s compensation as CEO for 2022 is summarized in the mix of our CEO pay which includes base salary, an annual performance-based restricted stock unit (“PRSU”) award, a RSU award,below table and, an option award and we did not substantially changedemonstrating the amounts of the equity awards. Demonstrating our pay for performance philosophy, the grant datenature of our program, his year-end value of the annual equity grants in 2020 was based on a stock price of $16.17 on June 12, 2020 and $34.33 on September 3, 2020 compared to the equity grants in 2021 with a stock price of $34.90 on April 30, 2021. However, on March 12, 2022, the effective date of the compensation committee’s certification of the number of 2021 PRSUs that were earned, the closing stock price was $7.26. As a result, the 2021 total compensation as of that date, substituting the value of the PRSUs earned, wasis significantly less than the grant date total compensation as shown below:value. See our Pay for Performance Table below.
| 2021 | 2020 | |||||||||||
| CEO Total Direct Compensation | ||||||||||||
| Base Salary | $500,000 | $451,346 | ||||||||||
| Option | ||||||||||||
| Number of Options | 69,500 | 42,200 | ||||||||||
| Grant Date Value | $1,560,991(1) | $423,507(2) | ||||||||||
| RSU | ||||||||||||
| Number of RSUs | 134,200 | 128,025 | ||||||||||
| Grant Date Value | $4,683,580(1) | $2,096,950(2) | ||||||||||
| PRSU | As of date earned | As of grant date | As of date earned | As of grant date | ||||||||
| Number of PRSUs | 44,117 | 59,700 | 53,436 | 56,250 | ||||||||
| Value | $320,289 | (3) | $2,083,530 | (1) | $2,281,717 | (4) | $909,562 | (2) | ||||
| TOTAL VALUE | $7,064,860 | (5) | $8,828,101 | $5,253,520 | (5) | $3,881,365 | ||||||
| 2022 | 2021 | ||||
| CEO Total Direct Compensation | |||||
| Base Salary | $750,000 | $500,000 | |||
| Reported Earned Bonus | $786,875 | – | |||
| Option | As of 12/31/2022 | As of grant date | |||
| Number of Options | 1,000,000 | 1,000,000 | 69,500 | ||
| Value | $1,490,000(1) | $1,962,800(2) | $1,560,991(3) | ||
| RSU | As of 12/31/2022 | As of grant date | |||
| Number of RSUs | 225,000 | 225,000 | 134,200 | ||
| Value | $418,500(1) | $1,588,500(2) | $4,683,580(3) | ||
| PRSU | – | As of date earned | As of grant date | ||
| Number of PRSUs | – | 44,117 | 59,700 | ||
| Value | – | $320,289(4) | $2,083,530(3) | ||
| As of 12/31/2022 | As of grant date | As of date earned | As of grant date | ||
| TOTAL VALUE | $3,445,375(5) | $5,088,175 | $7,064,860(6) | $8,828,101 | |
| (1) | The |
| (2) | The options are valued using a Black-Scholes valuation model as of the |
| (3) | The options are valued using a Black-Scholes valuation model as of the date of grant. The RSUs and PRSUs are valued using a stock price of $34.90 |
| The value of the PRSUs earned for 2021 based on the closing stock price of $7.26 on March 12, 2022, the effective date of the compensation committee’s certification of the number of 2021 PRSUs that were earned. | |
| The equity award values reported in the Summary Compensation Table are different than the total as of December 31, 2022 because they are based on the grant date value of the | |
| The equity award values reported in the Summary Compensation Table are different than the total earned because they are based on the grant date value of the annual equity awards and the target values of the PRSUs. |
Our Compensation Program Benefits Our Stockholders
We are committed to sound executive compensation policies and practices, as highlighted in the following table.
| What We Do | What We Do Not Do | |||
  | Rigorous, objective performance goals |   | No “golden parachute” gross-ups | |
| Limited perquisites | | No dividends paid on unvested shares | |
| Clawback policy covering cash incentives and stockawards | | No options/SARs granted below fair market value | |
| Independent compensation consultant and compensationcommittee | | No repricing of options without stockholder approval | |
| Annual risk assessment of compensation policies andprograms | | No excessive severance | |
| No guaranteed salary increases, bonuses, or long-term incentive awards | |||
INVITAE CORPORATION• 20222023 Proxy Statement 2224
Invitae relies on stockholder outreach as well as more formal channels to communicate with stockholders, including the opportunity for stockholders to cast a non-binding advisory vote regarding executive compensation at Invitae’s annual meeting of stockholders. In evaluating our compensation practices in fiscal 2021,2022, the compensation committee was mindful of the support our stockholders expressed for Invitae’s philosophy and practice of linking compensation to operational objectives and the enhancement of stockholder value.
Our Say-on-Pay approval rating was 98.4%95.5% of the votes cast in 2021.2022. The compensation committee took this vote into account in designing and implementing the 20212022 program. Based on input from our stockholders and our proxy advisors, we increased the number of performance metrics for our PRSUs from one to four.
During 2021,2022, the compensation committee continued to monitor our executive compensation programs to ensure compensation is aligned with company performance. The compensation committee will continue to seek out and consider stockholder feedback in the future and administer the pay for performance program in the interests of stockholders.
We compensate our named executive officers for achievement of short and long-term financial and operating goals and have competitive base salaries with nolimited perks, excessive severance, or deferred compensation.
Our compensation program is designed to attract executives with appropriate expertise and experience and is flexible enough to adapt to economic, social and regulatory changes while considering the compensation programs of our peer companies.
Our compensation program is aligned not only with stockholder interests but also with the interests of our customers and our employees.
We establish total direct compensation for our named executive officers consisting of the following components:
| • | Base |
| • | Annual |
| • | Time-Based Restricted Stock Unit |
| • | Option |
INVITAE CORPORATION• 20222023 Proxy Statement 2325
The main elements of our executive compensation program include: (1) base salary, (2) PRSUs,annual incentive cash awards, (3) time-based RSU awards, and (4) for our CEO, time-based option awards. We describe each of these elements below and explain what we paid in 20212022 and why.
The compensation committee’s independent compensation consultant, Compensia, reviewed our named executive officers’ 20212022 compensation and noted the base salary and short- and long-term equity incentives are competitive with the amounts paid by peers and are reflective of market practice by having the majority of total compensation based on short- and long-term incentives.
CEO and Other NEOs’ Pay Mix
| Includes only compensation of Mr. Knight, our CEO as of December 31, 2022. The base salary used represents an annualized base salary following Mr. Knight’s appointment as our CEO. Stock Options, Non-Equity Incentive Plan and RSU compensation are as reported in the Summary Compensation Table of this Proxy Statement. | |
| * | Does not include Ms. Wen’s signing bonus because it is not a component of the main elements of our regular executive compensation program. |
In the spring of 2020, the base salaries of our executive officers that were approved for 2020 were reduced as part of the Company’s response to the COVID-19 pandemic. Effective January 1, 2021, the base salaries of our named executive officers were restored to pre-reduction levels that were approved for 2020: Dr. George: $500,000; Mr. Knight $500,000; Mr. Brida $425,000; and Ms. Guyer $425,000. Mr. Nussbaum’s salary was increased to $400,000 ($25,000 increase from 2020) as result of the annual salary review process. In connection with her hiring andhis appointment as Chief FinancialExecutive Officer, a base salary of $475,000$750,000 was approved for Mr. Knight. The following base salaries were approved for our other named executive officers for 2022: Ms. Wen. Ms. Wen also receivedWen: $475,000 (no change from 2021); Mr. Brida $425,0000 (no change from 2021); Dr. Nussbaum: $400,000 ($25,000 increase as a $500,000 signing bonus payment, which must be repaid if she resigns before the anniversary of her start date. Effective October 21, 2021, Ms. Guyer’s salary was increased as partresult of the 2021 annual salary review process.process); and Dr. George: $500,000 (no change from 2021) up until his transition from the CEO role.
Under our 20212022 Executive Management Incentive Compensation Plan (the “Incentive Plan”), effective as of January 1, 2021,2022, our named executive officers were eligible to receive incentive compensation in the form of PRSUscash based on achievement of fourthree performance measures, which includewere cash burn, revenue selling and marketing expense as a percentage of revenue, and accession volume.non-GAAP gross margin. For 2021, PRSU2022, target amounts for our named executive officers were as follows:
| Name | |
| Kenneth D. Knight | 1,125,000 |
| Yafei (Roxi) Wen | 600,000 |
| Thomas R. Brida | 500,000 |
| Robert L. Nussbaum, MD | 500,000 |
| Sean E. George, | |
INVITAE CORPORATION• 20222023 Proxy Statement 2426
The companyCompany’s performance goals measured for theour named executive officers were:
| % of 2022 | |
| Annual Incentive Program Performance Goal | Target |
The Incentive Plan bases payouts upon relative achievement of a target, with ranges of payout calculations from 0% to 200% for each Target) based upon approved models for each target.
The Incentive Plan provides the following definitions for performance goals:
| • | “Cash Burn” is the net decrease in cash, cash equivalents, restricted cash and marketable securities, adjusted to remove acquisition related payments, restructuring-related cash payments and cash received from asset sales. A reconciliation of this non-GAAP financial metric to the closest GAAP equivalent is presented in Annex A. |
| • | “Revenue” is GAAP revenue recorded in the Company’s filings with the SEC, excluding any deferred revenue from the Company’s base business or acquired businesses. |
| • | “Non-GAAP Gross Margin” is Revenue less the non-GAAP cost of revenue, divided by Revenue, where the non-GAAP cost of revenue is defined as the GAAP cost of revenue recorded in the Company’s filings with the SEC, excluding the following acquisition-related expenses: (1) amortization of intangible assets; (2) stock-based compensation; (3) post-combination expenses; and (4) fair value adjustments to assets and liabilities. A reconciliation of these non-GAAP financial metrics to the closest GAAP equivalent is presented in Annex A. |
The Revenue performance target was established prior to our strategic realignment when our Revenue guidance was significantly decreased. We did not reset the Revenue targets in light of this updated Revenue guidance and the Revenue performance threshold was not achieved.
As determined by the compensation committee, the revenueCash Burn threshold, target, maximum and the actual results for 20212022 were as follows:
| Cash Burn ($ in millions) | Payout | ||
| 2022 Threshold | 670 | 0% | |
| 2022 Target | 595 | 100% | |
| 2022 Maximum | 395 | 200% | |
| 2022 Actual | 500.8 | 147.6% |
As determined by the compensation committee, the selling and marketing expense as a percentage of revenuenon-GAAP Gross Margin threshold, target and maximum and the results for 20212022 were as follows:
| Selling and Marketing Expense as Percent of Revenue* | Payout | |
| 2021 Threshold | 58.75% | 75% |
| 2021 Target/Maximum | 47% | 100% |
| 2021 Actual | 44% | 100% |
| Non-GAAP Gross Margin | Payout | ||
| 2022 Threshold | 41% | 0% | |
| 2022 Target | 48% | 100% | |
| 2022 Maximum | 50% | 200% | |
| 2022 Actual | 43%* | 62% |
| * | Non-GAAP |
The earned PRSU levels also depend on attainment of specific accession volume goals. We do not disclose our accession volume goals because we consider it competitively harmful to make that information public. This portion of the PRSU award is calculated based on a percentage of goals attained, with a maximum possible attainment of 125%. The accession volume goal was achieved at approximately 103%.
The cash burn performance targets and thresholds were not achieved, and the payout for this portion of the PRSU award was 0%.
To the extent actual performance fell between two discrete points as set forth in the charts above, linear interpolation was used to determine the payout percentage for each goal.
Based on the 20212022 audited financial results, our compensation committee determined the PRSUsincentive awards earned at approximately 74%69.9%. On March 12, 2022,January 26, 2023, the compensation committee accordingly grantedapproved the following PRSUs,payments, with one half of the total PRSUs vesting on March 12, 2022paid shortly after such date and the remaining PRSUs vestingpaid on March 12, 2023,the first anniversary thereof, subject to continued employment:employment (except for Dr. George, who received his full payment in early 2023 pursuant to the Transition Agreement described below):
| 2022 Incentive Plan Payouts | ||
| Name | ||
| Kenneth D. Knight | 786,875 | |
| Yafei (Roxi) Wen | 419,666 | |
| Thomas R. Brida | 349,722 | |
| Robert L. Nussbaum, MD | 349,722 | |
| Sean E. George, | ||
INVITAE CORPORATION• 20222023 Proxy Statement 2527
On April 30, 2021,9, 2022, our named executive officers, other than Ms. Wen and Ms. Guyer,Dr. George, were granted retention RSUs that vest in three equal annual installments with one third vesting on each of May 15, 2022, the second third of such sharesbeginning on May 15, 2023, and the final third of such shares on May 15, 2024, subject to such named executive officer’s continued service. Based on her transition from CFO to a new role as head of our ESG initiatives, Ms. Guyer received an award on May 6, 2021 equal to 27,000 RSUs that vest in four equal installments, with 25% of the award vesting on each of May 15, 2021, May 15, 2022, May 15, 2023, and May 15, 2024 and an award on September 24, 2021 equal to 34,000 RSUs that vest in three equal installments, with one third vesting on each of August 15, 2022, the second third of such shares on August 15, 2023, and the final third of such shares on August 15, 2024 with each award subject to continuous service. As part of an adjustment resulting from the change to the review process timeline, Ms. Guyer also received an award on October 5, 2021 equal to 183 RSUs that fully vested on November 15, 2021. Ms. Wen received her annual award on June 21, 2021, subject to continuous service, equal to 125,000 RSUs that vest in three equal installments, with one third vesting on each of May 15, 2022, the second third of such shares on May 15, 2023, and the final third of such shares on May 15, 2024.
| RSU | |
| Kenneth D. Knight | 225,000 |
| Yafei (Roxi) Wen | |
| Thomas R. Brida | |
| Robert L. Nussbaum, | |
Option Awards
On April 30, 2021,August 22, 2022, our named executive officers, other than Ms. WenMr. Knight and Ms. Guyer,Dr. George, were granted optionsadditional retention RSUs that vest in full on August 15, 2023, subject to such named executive officer’s continued service.
| RSU | |
| Name | (#) |
| Yafei (Roxi) Wen | 102,000 |
| Thomas R. Brida | 54,000 |
| Robert L. Nussbaum, MD | 54,000 |
On July 16, 2022, in connection with his transition from Chief Operating Officer to Chief Executive Officer, Mr. Knight was granted an option to purchase 1,000,000 shares of common stock with an exercise price of $34.90$2.85 per share, ourthe closing stock price of our common stock on the grant date.July 15, 2022. The option awards vestaward vests over four yearsa four-year period, subject to continued service, with 25% of the awardshares vesting on the one-yearfirst anniversary of the grant date and 1/48th of the awardremaining 75% vesting each month thereafter, subject to such named executive officer’s continued service.monthly over the following three years. The stock options are valued at $22.46$1.9628 per share, reflecting a grant date stock price of $34.90$2.85 and a Black-Scholes value of 64.36%68.87%.
In connection with his service on the board of directors following his transition from the Chief Executive Officer role through December 31, 2022, Dr. George was granted an option to purchase 8,050 shares of common stock with an exercise price of $2.85 per share, the closing stock price of our common stock on July 15, 2022. This option vested in full on December 15, 2022. The stock options are valued at $1.0512 per share, reflecting a grant date stock price of $2.85 and a Black-Scholes value of 36.88%.
We provide limited perquisites to our named executive officers that do not exceed the disclosure threshold. We have a 401(k) plan but no deferred compensation plan for executives. In April 2021, our board of directors approved change in control and severance agreements for our named executive officers, which provide for customary severance and change of control benefits as recommended by the compensation committee’s independent compensation consultant and competitive with our peer group. The severance and change in control agreements are further described in the “Potential Payments upon Termination or Change in Control” section below.
On July 16, 2022, Mr. Knight succeeded Dr. George as CEO and Dr. George entered into a Transition and Separation Agreement (the “Transition Agreement”) with the Company on July 17, 2022. Dr. George did not receive an equity grant for 2022. Pursuant to his preexisting Change of Control and Severance Agreement dated April 23, 2021, he received (x) a lump sum cash severance payment equal to 150% of his annual base salary of $500,000 for a payment of $750,000, (y) a lump sum cash payment equal to 18 months of COBRA premiums, and (z) 70% of his target cash bonus amount of $833,000 for a payment of $582,637, in each case subject to execution and delivery of an effective release of claims and satisfaction of certain restrictive covenants.
Pursuant to the Transition Agreement, Dr. George will serve in an on-call consulting role with the Company (including non-compete covenants) with the following compensation arrangements (assuming continued performance under and compliance with the Transition Agreement): (i) the existing RSUs and performance stock units held by Dr. George that would otherwise vest within 12 months following Dr. George’s transition from the CEO role (for a total of 108,975 shares) will vest on December 15, 2022; (ii) the existing RSUs held by Dr. George that would otherwise vest within the period of 13- to 24-months following Dr. George’s transition from the CEO role (for a total of 44,734 shares) will vest on June 15, 2023; and (iii) Dr. George agreed that all of his options to acquire shares of common stock will stop vesting as of his transition from the CEO role and the exercise period for such options will terminate 90 days thereafter.
INVITAE CORPORATION• 20222023 Proxy Statement 2628
The following policies and the chart below align management and stockholder interests, and mitigate any potential incentive for management to take inappropriate risks:
| • | Insider Trading Policy: This policy is distributed to all employees, directors and contractors. All employees, directors and contractors are prohibited from buying or selling during predetermined closed window periods. In addition, executive officers and directors are required to obtain pre-clearance from our General Counsel or Chief Financial Officer prior to making any trades or entering into any 10b5-1 trading plans. All directors and executive officers are required to enter into 10b5-1 plans. | |
| • | Hedging and Pledging: All executive officers, directors, and employees are prohibited from hedging or pledging stock under our Insider Trading and Communications Policy. We made exceptions to our no-pledging policy for our former Chief Executive Officer for real property purchase and construction costs, and for an employee. | |
| • | ||
| • | the incremental portion of cash incentive awards paid to executive officers in excess of the awards that would have been paid based on the restated financial results; and | |
| • | the incremental share of our common stock settled for PRSUs in excess of the shares of our common stock that would have been settled for such PRSUs based on the restated financial results, or the value of such incremental shares to the extent an executive officer sells any incremental shares. | |
| • | Severance and Change of Control | |
Our board of directors and the compensation committee are required to assess whether our compensation policies and practices and, in particular, our performance-based compensation practices, encourage executive officers or other employees to take unnecessary or unreasonable risks that could threaten the long-term value of the Company or that are reasonably likely to have a material adverse effect on the Company. Management believes that our practices adequately manage this risk because:
| • | our executive compensation is benchmarked by our independent compensation consultant to our peers; |
| • | bonuses are capped; |
| • | our bonus plan preserves discretion to permit the compensation committee to elect not to pay otherwise achieved bonus amounts for any reason; |
| • | a meaningful component of compensation is equity grants with extended vesting periods designed to ensure that our executives value and focus on our long-term performance; and |
| • | executive compensation is subject to our |
Our “clawback” policy will be amended to comply with the NYSE listing rules when such rules are effective.
The compensation committee begins its process of deciding how to compensate our named executive officers by considering the competitive market data provided by our People & Culture team and Compensia. The compensation committee engaged Compensia to provide prospective advice and recommendations on competitive market practices and compensation decisions.
Beginning in 2020, Compensia began reviewing our peer group using a defined methodology that identifies companies with attributes reasonably and objectively like ours in terms of industry, industry profile, size, and market capitalization to revenue ratio and profit margins. Below is the list of the peer companies used for 20212022 compensation decisions:
| 10x | Natera | |
| ACADIA | ||
| Nevro | ||
| Sarepta | ||
| Vir |
* New peer group companies.
INVITAE CORPORATION• 20222023 Proxy Statement 2729
In 2021,December 2022, we determined that the above peer group remained reasonable for purposes of competitive comparison and made no changes torevised our peer group for 2022.to better align peers to our current market capitalization.
Below is the list of the peer companies used for 2023 compensation decisions:
| 23andMe* | Cue Health* | NeoGenomics* |
| Adaptive Biotechnologies | Dynavax Technologies* | Nevro |
| AngioDynamics* | Guardant Health | OraSure Technologies* |
| ANI Pharmaceuticals* | Inotiv* | Orthofix Medical* |
| Cardiovascular Systems* | iTeos Therapeutics* | Sema4 Holdings (now GeneDX Holdings)* |
| CareDx | Myriad Genetics | Varex Imaging* |
| Codexis* | Natera | Veracyte* |
* New peer group companies.
The positions of our named executive officers are compared to their counterpart positions in our peer group, and the compensation levels for comparable positions in that peer group are examined for guidance in determining:
| • | base salaries; |
| • | performance bonuses; and |
| • | the amount and mix of long-term, equity-based incentive awards. |
The compensation committee establishes base salaries, variable cash incentive awards, and long-term, equity-based incentive awards on a case-by-case basis for each named executive officer taking into account, among other things, individual and company performance, role expertise and experience and the competitive market, advancement potential, recruiting needs, internal equity, retention requirements, unrealized equity gains, succession planning and best compensation governance practices. The compensation committee does not tie individual compensation to specific target percentiles.
The compensation committee seeks input and recommendations from our Chief Executive Officer and our People & Culture team, but makes all executive compensation and benefits determinations without delegation. Our Chief Executive Officer also does not participate in determinations with respect to his own compensation. Compensia provides the compensation committee assistance in satisfying its duties, but Compensia will not undertake a project for management except at the request of the compensation committee chair, in the capacity of the compensation committee’s agent, and where such a project is in direct support of the compensation committee’s charter. The compensation committee assessed the independence of Compensia in 2021, taking into consideration applicable SEC rules and regulations, and NYSE independence factors regarding advisor independence, and believes that there are no conflicts of interest. The major topics covered at each compensation committee meeting are reported to the board of directors.
The Company considers the effects of Section 162(m) of the Internal Revenue Code, which generally disallows the tax deduction for compensation in excess of $1 million for certain covered individuals. The compensation committee believes that stockholder interests are best served if its discretion and flexibility in awarding compensation is not restricted, even though some compensation awards may result in non-deductible compensation expenses. Therefore, the compensation committee has approved salaries and other awards for executive officers that were not fully deductible because of Section 162(m) and, in light of the repeal of the performance-based compensation exception to Section 162(m), expects in the future to approve additional compensation that is not deductible for income tax purposes.
INVITAE CORPORATION • 2023 Proxy Statement 30
The following report of the compensation committee shall not be deemed to be “soliciting material” or “filed” with the SEC or to be incorporated by reference into any other filing by Invitae Corporation under the Securities Act of 1933 or the Securities Exchange Act of 1934, except to the extent that we specifically incorporate it by reference into a document filed under those Acts.
The compensation committee has reviewed and discussed the Compensation Discussion and Analysis set forth above with our management. Based on its review and those discussions, the compensation committee recommended to the board of directors that the Compensation Discussion and Analysis be included in this Proxy Statement and incorporated by reference into our Annual Report on Form 10-K for the year ended December 31, 2021.2022.
Compensation Committee
Geoffrey S. Crouse, Chair
Eric Aguiar, M.D.
MD
Christine M. Gorjanc
INVITAE CORPORATION• 20222023 Proxy Statement 2831
The following table sets forth information concerning the total compensation of the following persons, whom we refer to as our named executive officers: our current and former Chief Executive Officer, our current and former Chief Financial Officer and our threetwo other most highly compensated individuals who were serving as executive officers of the Company on December 31, 2021.2022.
| Name and principal position | Fiscal Year | Salary ($) | (1) | Stock Awards ($) | (2) | Option Awards ($) | (3) | Non-Equity Incentive Plan Compensation ($) | (4) | All Other Compensation ($) | Total ($) | |||
Sean E. George, Ph.D. President and Chief | 2021 | 500,000 | 6,767,110 | 1,560,991 | — | 153 | 8,828,254 | |||||||
| 2020 | 451,346 | 3,006,513 | 423,507 | — | — | 3,881,365 | ||||||||
| 2019 | 500,000 | 2,714,400 | 2,105,110 | 166,788 | — | 5,486,298 | ||||||||
Yafei (Roxi) Wen Chief Financial Officer | 2021 | 246,635 | 4,830,966 | — | — | — | 5,077,601 | |||||||
Shelly D. Guyer(5) Chief Sustainability Officer, | 2021 | 429,904 | 1,822,299 | — | — | 540 | 2,252,742 | |||||||
| 2020 | 383,644 | 1,423,933 | 196,700 | — | — | 2,004,277 | ||||||||
| 2019 | 425,000 | 2,488,200 | — | 141,769 | — | 3,054,969 | ||||||||
Thomas R. Brida General Counsel, | 2021 | 425,000 | 2,254,540 | 521,079 | — | — | 3,200,619 | |||||||
| 2020 | 348,752 | 1,424,071 | 196,700 | — | — | 1,969,523 | ||||||||
Kenneth D. Knight(6) Chief Operating Officer | 2021 | 500,000 | 2,254,540 | 521,079 | — | 500,066 | 3,775,685 | |||||||
| 2020 | 250,000 | 10,760,750 | — | — | — | 11,010,750 | ||||||||
Robert L. Nussbaum, M.D. Chief Medical Officer | 2021 | 391,346 | 2,254,540 | 521,079 | — | — | 3,166,965 | |||||||
| 2020 | 338,510 | 1,418,887 | 196,700 | — | — | 1,954,097 | ||||||||
| 2019 | 375,000 | 2,488,200 | — | 125,091 | — | 2,988,291 |
| Name and principal position | Fiscal Year | Salary ($) | (1) | Stock Awards ($) | (2) | Option Awards ($) | (3) | Non-Equity Incentive Plan Compensation ($) | (4) | All Other Compensation ($) | (5) | Total ($) | ||
| Kenneth D. Knight | 2022 | 610,577 | (6) | 1,588,500 | 1,962,800 | 786,875 | 2,000 | 4,950,752 | ||||||
| Chief Executive Officer | 2021 | 500,000 | 2,254,540 | 521,079 | – | 501,566 | 3,777,185 | |||||||
| 2020 | 250,000 | 10,760,750 | – | – | 1,500 | 11,012,250 | ||||||||
| Yafei (Roxi) Wen | 2022 | 475,000 | 1,928,160 | – | 419,666 | 502,000 | (7) | 3,324,826 | ||||||
| Chief Financial Officer | 2021 | 246,635 | 4,830,966 | – | – | 1,500 | 5,079,101 | |||||||
| Thomas R. Brida | 2022 | 425,000 | 1,369,508 | – | 349,722 | 2,000 | 2,146,230 | |||||||
| General Counsel, Chief Compliance Officer and Secretary | 2021 | 425,000 | 2,254,540 | 521,079 | – | 1,500 | 3,202,119 | |||||||
| 2020 | 348,752 | 1,424,071 | 196,700 | – | 1,500 | 1,971,023 | ||||||||
| Robert L. Nussbaum, MD | 2022 | 400,000 | 1,369,508 | – | 349,722 | 2,229 | 2,121,459 | |||||||
| Chief Medical Officer | 2021 | 391,346 | 2,254,540 | 521,079 | – | 1,500 | 3,168,465 | |||||||
| 2020 | 338,510 | 1,418,887 | 196,700 | – | 1,500 | 1,955,597 | ||||||||
| Sean E. George, PhD | 2022 | 282,692 | – | – | 582,637 | 791,074 | (8) | 1,656,403 | ||||||
| Former President and Chief Executive Officer | 2021 | 500,000 | 6,767,110 | 1,560,991 | – | 153 | 8,828,254 | |||||||
| 2020 | 451,346 | 3,006,513 | 423,507 | – | – | 3,881,365 |
| (1) | The salary amounts reflect the actual base salary payments earned by our named executive officers in the applicable fiscal year. |
| (2) | The amounts in this column represent the aggregate fair value of the stock awards computed as of the grant date of each award in accordance with ASC 718, which was determined using the closing price of our common stock on the date of grant. With respect to fiscal |
| (3) | The amounts in this column represent the aggregate fair value of the option awards computed as of the grant date of each award in accordance with ASC 718 for financial reporting purposes, rather than amounts paid to or realized by the individual. See the notes to our consolidated financial statements in our Annual Report on Form 10-K for the year ended December 31, |
| (4) | |
| (5) | All Other Compensation includes matching contributions under the 401(k) plan made by the Company for each fiscal year in the amount of $1,500 for each of Mr. Knight, Ms. |
| (6) | Salary reflects an increase in Mr. Knight’s annual base salary to $750,000 effective July 16, 2022. |
| (7) | All Other Compensation includes a signing bonus paid in |
| (8) | Represent a lump sum cash severance payment equal to 150% of his annual base salary of $500,000 for a payment of $750,000 and a lump sum cash payment equal to 18 months of COBRA premiums. |
INVITAE CORPORATION • 20222023 Proxy Statement 2932
The following table presents information regarding grants of plan-based awards to each of our named executive officers during the fiscal year ended December 31, 2021:2022:
| Estimated Future Payouts Under Equity Incentive Plan Awards(1) | All Other Stock | All Other Option Awards: | Exercise | Grant Date | ||||||||||||
| Name | Grant Date | Threshold ($) | Target ($) | Maximum ($) | Awards: Number of Shares of Stock or Units (#) | (2) | Number of Securities Underlying Options (#) | (3) | or Base Price of Option Awards ($/Share) | Fair Value of Stock and Option Awards ($) | ||||||
| Sean E. George, Ph.D. | 4/30/2021 | 42,536 | 59,700 | 67,162 | — | — | — | 2,083,530 | ||||||||
| 4/30/2021 | — | — | — | 134,200 | — | — | 4,683,580 | |||||||||
| 4/30/2021 | — | — | — | — | 69,500 | 34.90 | 1,560,991 | |||||||||
| Yafei (Roxi) Wen | 6/21/2021 | 14,178 | 19,900 | 22,387 | — | — | — | 663,466 | ||||||||
| 6/21/2021 | — | — | — | 125,000 | — | — | 4,167,500 | |||||||||
| Shelly D. Guyer | 5/6/2021 | — | — | — | 27,000 | (4) | — | — | 795,420 | |||||||
| 9/24/2021 | — | — | — | 34,000 | (5) | — | — | 1,022,040 | ||||||||
| 10/5/2021 | — | — | — | 183 | (6) | — | — | 4,839 | ||||||||
| Thomas R. Brida | 4/30/2021 | 14,178 | 19,900 | 22,387 | — | — | — | 694,510 | ||||||||
| 4/30/2021 | — | — | — | 44,700 | — | — | 1,560,030 | |||||||||
| 4/30/2021 | — | — | — | — | 23,200 | 34.90 | 521,079 | |||||||||
| Kenneth D. Knight | 4/30/2021 | 14,178 | 19,900 | 22,387 | — | — | — | 694,510 | ||||||||
| 4/30/2021 | — | — | — | 44,700 | — | — | 1,560,030 | |||||||||
| 4/30/2021 | — | — | — | — | 23,200 | 34.90 | 521,079 | |||||||||
| Robert L. Nussbaum, M.D. | 4/30/2021 | 14,178 | 19,900 | 22,387 | — | — | — | 694,510 | ||||||||
| 4/30/2021 | — | — | — | 44,700 | — | — | 1,560,030 | |||||||||
| 4/30/2021 | — | — | — | — | 23,200 | 34.90 | 521,079 | |||||||||
| Estimated Future Payouts Under Non-Equity Incentive Plan Awards(1) | All Other Stock Awards: Number of Shares of | All Other Option Awards: Number of Securities | Exercise or Base Price | Grant Date Fair Value of Stock | ||||||||||||
| Name | Grant Date | Threshold ($) | Target ($) | Maximum ($) | Stock or Units (#) | Underlying Options (#) | of Option Awards ($/Share) | and Option Awards ($) | ||||||||
| Kenneth D. Knight | 4/9/2022(2) | – | 1,125,000 | 2,225,000 | 225,000 | – | – | 1,588,500 | ||||||||
| 7/16/2022(3) | – | – | – | – | 1,000,000 | 2.85 | 1,962,800 | |||||||||
| Yafei (Roxi) Wen | 4/9/2022(2) | – | 600,000 | 1,200,000 | 225,000 | – | – | 1,588,500 | ||||||||
| 8/22/2022(4) | – | – | – | 102,000 | – | – | 339,660 | |||||||||
| Thomas R. Brida | 4/9/2022(2) | – | 500,000 | 1,000,000 | 168,511 | – | – | 1,189,688 | ||||||||
| 8/22/2022(4) | – | – | – | 54,000 | – | – | 179,820 | |||||||||
| Robert L. Nussbaum, MD | 4/9/2022(2) | – | 500,000 | 1,000,000 | 168,511 | – | – | 1,189,688 | ||||||||
| 8/22/2022(4) | – | – | – | 54,000 | – | – | 179,820 | |||||||||
| Sean E. George, PhD | 4/9/2022 | – | 833,000 | 1,666,000 | – | – | – | – | ||||||||
| (1) | These |
| (2) | |
| (3) | These options were granted pursuant to the 2015 Stock |
| (4) | |
INVITAE CORPORATION • 20222023 Proxy Statement 3033
The following table sets forth information regarding outstanding equity awards for each of our named executive officers as of December 31, 2021:2022:
| Option Awards | Stock Awards | ||||||||||||||||||
| Name | Date Granted | Number of Securities Underlying Unexercised Options Exercisable (#) | Number of Securities Underlying Unexercised Options Unexercisable (#) | Option Exercise Price ($) | Option Expiration Date | Number of Shares or Units of Stock that have not Vested (#) | Market Value of Shares or Units of Stock that have not Vested ($) | (1) | Equity Incentive Plan Awards: Number of Unearned Shares, Units or Other Rights that have Not Vested (#) | Equity Incentive Plan Awards: Market or Payout Value of Unearned Shares, Units or Other Rights That Have Not Vested ($) | (1) | ||||||||
| Sean E. George, Ph.D. | 4/30/2021 | — | 69,500 | 34.90 | 4/30/2031 | (2) | 134,200 | (3) | 2,049,234 | 59,700 | (4) | 911,619 | |||||||
| 6/12/2020 | 15,825 | 26,375 | 16.17 | 6/12/2030 | (2) | 84,367 | (5) | 1,288,284 | 26,718 | (6) | 407,984 | ||||||||
| 5/2/2019 | 93,645 | 51,355 | 24.16 | 5/2/2029 | (2) | — | — | — | — | ||||||||||
| 7/14/2019 | — | — | — | — | — | — | 33,357 | (7) | 509,361 | ||||||||||
| 6/22/2018 | 175,000 | 25,000 | 8.08 | 6/22/2028 | (2) | — | — | — | — | ||||||||||
| 2/3/2017 | 252,648 | — | 9.06 | 2/3/2027 | (8) | — | — | — | — | ||||||||||
| 3/31/2016 | 70,000 | — | 10.23 | 3/31/2026 | (8) | — | — | — | — | ||||||||||
| 8/4/2015 | 180,000 | — | 9.90 | 8/4/2025 | (8) | — | — | — | — | ||||||||||
| 10/15/2014 | 35,000 | — | 8.70 | 10/15/2024 | (8) | — | — | — | — | ||||||||||
| Yafei (Roxi) Wen | 6/21/2021 | — | — | — | — | 125,000 | (3) | 1,908,750 | 19,900 | (4) | 303,873 | ||||||||
| Shelly D. Guyer | 9/24/2021 | — | — | — | — | 34,000 | (9) | 519,180 | — | — | |||||||||
| 5/6/2021 | — | — | — | — | 20,250 | (10) | 309,218 | — | — | ||||||||||
| 6/12/2020 | 7,350 | 12,250 | 16.17 | 6/12/2030 | (2) | 39,434 | (5) | 602,157 | 12,468 | (6) | 190,386 | ||||||||
| 7/14/2019 | — | — | — | — | — | — | 30,578 | (7) | 466,926 | ||||||||||
| 6/12/2017 | 100,000 | — | 9.18 | 6/12/2027 | (8) | — | — | — | — | ||||||||||
| Thomas R. Brida | 4/30/2021 | — | 23,200 | 34.90 | 4/30/2031 | (2) | 44,700 | (3) | 682,569 | 19,900 | (4) | 303,873 | |||||||
| 6/12/2020 | 7,350 | 12,250 | 16.17 | 6/12/2030 | (2) | 39,434 | (5) | 602,157 | 12,468 | (6) | 190,386 | ||||||||
| 7/14/2019 | — | — | — | — | — | — | 26,408 | (7) | 403,250 | ||||||||||
| 3/31/2016 | 2,100 | — | 10.23 | 3/31/2026 | (8) | — | — | — | — | ||||||||||
| 2/1/2016 | 9,000 | — | 7.01 | 2/1/2026 | (8) | — | — | — | — | ||||||||||
| Kenneth D. Knight | 4/30/2021 | — | 23,200 | 34.90 | 4/30/2031 | (2) | 44,700 | (3) | 682,569 | 19,900 | (4) | 303,873 | |||||||
| 8/4/2020 | — | — | — | — | 166,667 | (11) | 2,545,005 | — | — | ||||||||||
| Robert L. Nussbaum, M.D. | 4/30/2021 | — | 23,200 | 34.90 | 4/30/2031 | (2) | 44,700 | (3) | 682,569 | 19,900 | (4) | 303,873 | |||||||
| 6/12/2020 | 7,350 | 12,250 | 16.17 | 6/12/2030 | (2) | 39,434 | (5) | 602,157 | 12,468 | (6) | 190,386 | ||||||||
| 7/14/2019 | — | — | — | — | — | — | 30,578 | (7) | 466,926 | ||||||||||
| 3/31/2016 | 53,594 | — | 10.23 | 3/31/2026 | (8) | — | — | — | — | ||||||||||
| 8/4/2015 | 40,080 | — | 9.90 | 8/4/2025 | (8) | — | — | — | — | ||||||||||
| Option Awards | Stock Awards | |||||||||||||||
| Name | Date Granted | Number of Securities Underlying Unexercised Options Exercisable (#) | Number of Securities Underlying Unexercised Options Unexercisable (#) | Option Exercise Price ($) | Option Expiration Date | Number of Shares or Units of Stock that have not Vested (#) | Market Value of Shares or Units of Stock that have not Vested ($) | (1) | ||||||||
| Kenneth D. Knight | 4/9/2022 | – | – | – | – | 225,000 | (2) | 418,500 | ||||||||
| 7/16/2022 | – | 1,000,000 | 2.85 | 7/16/2032 | (3) | – | – | |||||||||
| 4/30/2021 | – | – | – | – | 7,352 | (4) | 13,675 | |||||||||
| 4/30/2021 | 9,666 | 13,534 | 34.90 | 4/30/2031 | (3) | 29,800 | (5) | 55,428 | ||||||||
| 8/4/2020 | – | – | – | – | 83,334 | (6) | 155,001 | |||||||||
| Yafei (Roxi) Wen | 4/9/2022 | – | – | – | – | 225,000 | (2) | 418,500 | ||||||||
| 8/22/2022 | – | – | – | – | 102,000 | (7) | 189,720 | |||||||||
| 6/21/2021 | – | – | – | – | 7,352 | (4) | 13,675 | |||||||||
| 6/21/2021 | – | – | – | – | 83,334 | (5) | 155,001 | |||||||||
| Thomas R. Brida | 4/9/2022 | – | – | – | – | 168,511 | (2) | 313,430 | ||||||||
| 8/22/2022 | – | – | – | – | 54,000 | (7) | 100,440 | |||||||||
| 4/30/2021 | – | – | – | – | 7,352 | (4) | 13,675 | |||||||||
| 4/30/2021 | 9,666 | 13,534 | 34.90 | 4/30/2031 | (3) | 29,800 | (5) | 55,428 | ||||||||
| 6/12/2020 | 12,250 | 7,350 | 16.17 | 6/12/2030 | (3) | 19,717 | (8) | 36,674 | ||||||||
| 3/31/2016 | 2,100 | – | 10.23 | 3/31/2026 | (9) | – | – | |||||||||
| 2/1/2016 | 9,000 | – | 7.01 | 2/1/2026 | (9) | – | – | |||||||||
| Robert L. Nussbaum, MD | 4/9/2022 | – | – | – | – | 168,511 | (2) | 313,430 | ||||||||
| 8/22/2022 | – | – | – | – | 54,000 | (7) | 100,440 | |||||||||
| 4/30/2021 | – | – | – | – | 7,352 | (4) | 13,675 | |||||||||
| 4/30/2021 | 9,666 | 13,534 | 34.90 | 4/30/2031 | (3) | 29,800 | (5) | 55,428 | ||||||||
| 6/12/2020 | 12,250 | 7,350 | 16.17 | 6/12/2030 | (3) | 19,717 | (8) | 36,674 | ||||||||
| 3/31/2016 | 53,594 | – | 10.23 | 3/31/2026 | (9) | – | – | |||||||||
| 8/4/2015 | 40,080 | – | 9.90 | 8/4/2025 | (9) | – | – | |||||||||
| Sean E. George, PhD | 4/30/2021 | – | – | – | – | 44,734 | (10) | 83,205 | ||||||||
INVITAE CORPORATION • 2022 Proxy Statement 31
| (1) | The aggregate dollar value is calculated using the closing price of our common stock on December |
| (2) | The RSUs vest in three equal installments, with one third of the total award vesting on each of May 15, 2023, 2024 and 2025, subject to continued service. |
| (3) | The option vests as to 25% of the shares on the |
| Represents the actual performance-based restricted stock unit payouts based on fiscal 2021 performance. One half of the awards vested on March 12, 2022, and the remainder vested on the first anniversary thereof. | |
| (5) | The RSUs vest in three equal installments, with one third of the total award vesting on each of May 15, 2022, 2023 and 2024, subject to continued service. |
| The RSUs vest in full on August 15, 2023, subject to continued service. | |
| (8) | The RSUs vest in three equal installments, with one third of the total award vesting on each of June 12, 2021, 2022 and 2023, subject to continued service. |
| The option is fully vested. | |
| The | |
INVITAE CORPORATION • 2023 Proxy Statement 34
The following table sets forth the dollar amounts realized pursuant to the vesting or exercise of equity-based awards by each of our named executive officers for the fiscal year ended December 31, 2022:
| Option Awards | Stock Awards | ||||||||
| Name | Number of Shares Acquired on Exercise (#) | Value Realized on Exercise ($) | Number of Shares Acquired on Vesting (#) | Value Realized on Vesting ($) | (1) | ||||
| Kenneth D. Knight | – | – | 105,586 | 477,749 | |||||
| Yafei (Roxi) Wen | – | – | 49,019 | 233,380 | |||||
| Thomas R. Brida | – | – | 80,846 | 498,773 | |||||
| Robert L. Nussbaum, MD | – | – | 85,016 | 529,047 | |||||
| Sean E. George, PhD | – | – | 294,075 | 1,262,178 | |||||
| (1) | Value realized upon vesting of RSUs is computed by multiplying the number of shares of common stock underlying RSUs that vested by the closing price of our common stock on the vesting date. |
In April 2021, our board of directors approved change in control and severance agreements for our named executive officers. These agreements provide for customary change in control and severance benefits which were recommended by the compensation committee’s independent compensation consultant and are competitive with our peer group.
Each agreement provides that, upon a change in control, performance-based equity awards will be deemed achieved at target for any unfinished performance period, will convert to time-vesting at target, and will continue to vest in accordance with any service-based vesting condition specified in the award agreement, subject to acceleration upon an involuntary termination within three months prior to or 12 months following the change in control.
In addition, each agreement provides that if the named executive officer is terminated by us without cause or is otherwise involuntarily terminated, as such terms are defined in the agreement, within three months prior to or 12 months following a change in control, the named executive officer will be entitled to receive (i) a lump sum cash severance payment equal to 100% (150% for our CEO) of the named executive officer’s annual base salary, (ii) any earned but unpaid annual bonus, (iii) a lump sum cash payment equal to 12 months (18 months for our CEO) of COBRA premiums, and (iv) acceleration of vesting as to 100% of the executive’s then outstanding unvested equity awards subject to time-based vesting.
Under the change in control and severance agreements, each named executive officer is also entitled to severance if the named executive officer is terminated without cause or otherwise involuntarily terminated other than in connection with a change in control. Specifically, each named executive officer is entitled to (i) a lump sum cash payment equal to 100% (150% for our CEO) of the named executive officer’s annual base salary, (ii) any earned but unpaid annual bonus, and (iii) a lump sum payment equal to 12 months (18 months for our CEO) of COBRA premiums. Payment of such severance benefits is subject to the named executive officer’s execution and delivery of an effective release of claims.
Should any portion of a named executive officer’s severance or other benefits constitute a “parachute payment” under Section 280G of the Internal Revenue Code, and therefore become subject to an excise tax under Section 4999 of the Internal Revenue Code, then such named executive officer shall receive the better of (i) the full amount of the severance and other benefits under the severance and change in control agreement or (ii) a lesser amount of the severance and other benefits such that no portion of such benefits is subject to an excise tax, in each case on an after-tax basis. We do not “gross up” our named executive officers for any 280G related excise taxes.
The following table sets forth potential payments payable to our current executive officers upon termination of employment or a change in control if the associated triggering event were to have occurred on December 31, 20212022 under the change in control and severance agreements and provisions that existed on such date. For accelerated equity awards, the amounts reflect the difference between the per share exercise price as of fiscal year end and the closing market price per share as of fiscal year end, $15.27.$1.86. The amounts listed in the table below are in addition to benefits generally available to our employees upon termination of employment, such as distributions from the 401(k) plan. The compensation committee may in its discretion revise, amend or add to the benefits if it deems advisable.
INVITAE CORPORATION • 20222023 Proxy Statement 3235
| Name | Termination Without Cause or Involuntary Termination; No Change in Control ($) | Termination Without Cause or Involuntary Termination with Change in Control ($) | Change in Control |
| Sean E. George, Ph.D. | |||
| Salary | 750,000 | 750,000 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 5,346,232 | — |
| Benefits Continuation | 37,010 | 37,010 | — |
| Yafei (Roxi) Wen | |||
| Salary | 475,000 | 475,000 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 2,212,623 | — |
| Benefits Continuation | 24,673 | 24,673 | — |
| Shelly D. Guyer | |||
| Salary | 446,250 | 446,250 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 2,087,867 | — |
| Benefits Continuation | 20,881 | 20,881 | — |
| Thomas R. Brida | |||
| Salary | 425,000 | 425,000 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 2,182,236 | — |
| Benefits Continuation | 6,952 | 6,952 | — |
| Kenneth D. Knight | |||
| Salary | 500,000 | 500,000 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 3,531,447 | — |
| Benefits Continuation | 14,487 | 14,487 | — |
| Robert L. Nussbaum, M.D. | |||
| Salary | 400,000 | 400,000 | — |
| Bonus | — | — | — |
| Equity Acceleration | — | 2,245,912 | — |
| Benefits Continuation | 8,216 | 8,216 | — |
The following table sets forth the dollar amounts realized pursuant to the vesting or exercise of equity-based awards by each of our named executive officers for the fiscal year ended December 31, 2021:
| Option Awards | Stock Awards | ||||||||
| Name | Number of Shares Acquired on Exercise (#) | Value Realized on Exercise ($) | (1) | Number of Shares Acquired on Vesting (#) | Value Realized on Vesting ($) | (2) | |||
| Sean E. George, Ph.D. | 83,333 | 2,538,904 | 135,592 | 4,751,840 | |||||
| Yafei (Roxi) Wen | — | — | — | — | |||||
| Shelly D. Guyer | — | — | 111,362 | 3,731,867 | |||||
| Thomas R. Brida | — | — | 86,926 | 3,014,773 | |||||
| Kenneth D. Knight | — | — | 120,833 | 3,455,782 | |||||
| Robert L. Nussbaum, M.D. | 39,776 | 703,267 | 104,429 | 3,540,690 | |||||
INVITAE CORPORATION • 2022 Proxy Statement 33
| Name | Termination Without Cause or Involuntary Termination; No Change in Control ($) | Termination Without Cause or Involuntary Termination with Change in Control ($) | Change in Control | |||
| Kenneth D. Knight | ||||||
| Salary | 750,000 | 750,000 | – | |||
| Bonus | – | – | – | |||
| Equity Acceleration | – | 624,604 | – | |||
| Benefits Continuation | 25,115 | 25,115 | – | |||
| Yafei (Roxi) Wen | ||||||
| Salary | 475,000 | 475,000 | – | |||
| Bonus | – | – | – | |||
| Equity Acceleration | – | 776,896 | – | |||
| Benefits Continuation | 24,717 | 24,717 | – | |||
| Thomas R. Brida | ||||||
| Salary | 425,000 | 425,000 | – | |||
| Bonus | – | – | – | |||
| Equity Acceleration | – | 519,647 | – | |||
| Benefits Continuation | 7,996 | 7,996 | – | |||
| Robert L. Nussbaum, MD | ||||||
| Salary | 400,000 | 400,000 | – | |||
| Bonus | – | – | – | |||
| Equity Acceleration | – | 519,647 | – | |||
| Benefits Continuation | 9,333 | 9,333 | – |
See “– Compensation Discussion and Analysis – Fiscal 2022 Compensation – Transition and Separation Agreement” for a discussion of payments to Dr. George upon his transition in July 2022.
As required by Section 953(b) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(u) of Regulation S-K, we are providing the following information about the relationship of the annual total compensation of our employees and the annual total compensation of Dr. Sean E. George,Kenneth D. Knight, our Chief Executive Officer.Officer as of December 31, 2022. The pay ratio included in this information is a reasonable estimate calculated in a manner consistent with Item 402(u) of Regulation S-K.
The SEC’s rules for identifying the median compensated employee and calculating the pay ratio based on that employee’s annual total compensation allow companies to adopt a variety of methodologies, to apply certain exclusions and to make reasonable estimates and assumptions that reflect their employee populations and compensation practices. As a result, the pay ratio reported by other companies may not be comparable to the pay ratio reported below, as other companies have different employee populations and compensation practices and may utilize different methodologies, exclusions, estimates and assumptions in calculating their own pay ratios.
We identified our median compensated employee from 2,9571,644 full-time and part-time workers who were included as employees on our payroll records as of December 31, 20212022 based on year-to-date base salary, bonus, commissions and equity as included in their W-2 forms, with conforming adjustments for employees who were hired during that period but did not work the full 12 months. We excluded the following number of employees from our foreign subsidiaries: Canada (27)(18), EMEA (78),(3) and APAC (39) and LATAM (9)(21).
The 20212022 annual total compensation as determined under Item 402 of Regulation S-K for our CEO was $8,828,254,$4,949,252, as reported in the Summary Compensation Table of this Proxy Statement. On an annualized basis, the 2022 total compensation for our CEO is $5,088,675. The 20212022 annual total compensation as determined under Item 402 of Regulation S-K for our median employee was $164,339.$133,919. The ratio of our CEO’s annual total compensation to our median employee’s total annual compensation for fiscal year 20212022 is 5438 to 1.
The price of our common stock experienced significant volatility in 20212022 which impacts the CEO pay ratio. In the calculations above, restricted stock units were valued at $34.90$7.06 and option awards at $22.46,$1.9628 , based on the closing price of our common stock on the date of grant.
INVITAE CORPORATION • 2023 Proxy Statement 36
As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act and Item 402(v) of Regulation S-K, the table below includes information to demonstrate the relationship between NEO compensation and certain financial performance measures for fiscal years 2020, 2021 and 2022. In the tables and charts below, we have selected the S&P 500 Healthcare Index as our peer group comparison for total shareholder return. This is the index we use for purposes of Rule 201(e)(1)(ii) of Regulation S-K.
For additional information about our performance-based pay philosophy and how we align executive compensation with our performance, refer to the Compensation Discussion and Analysis beginning on page 21.
| Value of Initial Fixed $100 Investment Based On: | ||||||||||||||||||||
| Year | Summary Compensation Table Total for PEO ($)(a) | Compensation Actually Paid to PEO ($)(b) | Average Summary Compensation Table Total for non-PEO Named Executive Officers ($)(a)(c) | Average Compensation Actually Paid to non-PEO Named Executive Officers ($)(b) | Company Total Shareholder Return ($) | S&P 500 Healthcare Index Total Shareholder Return ($)(d) | Net Loss ($ in millions) | Cash Burn ($ in millions)(e) | ||||||||||||
| George: | Knight: | George: | Knight: | |||||||||||||||||
| 2022 | 1,656,403 | 4,949,252 | (4,658,333) | 314,557 | 2,529,338 | (378,752) | 11.53 | 133.44 | 602.2 | 509.6 | ||||||||||
| 2021 | 8,828,254 | (3,925,307) | 3,494,722 | (1,336,005) | 94.67 | 138.35 | 379 | 849.2 | ||||||||||||
| 2020 | 3,881,365 | 17,612,219 | 3,798,621 | 8,812,173 | 259.21 | 111.43 | 3100 | 693.7 | ||||||||||||
| (a) | The dollar amounts reported are the total compensation reported for each fiscal year in the “Total” column of the Summary Compensation Table. |
| (b) | The dollar amounts reported in column (b) represent the amount of “compensation actually paid” in accordance with Item 402(v) of Regulation S-K. The dollar amounts do not reflect the actual amount of compensation earned by or paid during the applicable year. In accordance with the requirements of Item 402(v) of Regulation S-K, the following adjustments were made to our CEO’s total compensation for each year to determine the compensation actually paid: |
| Year | Reported Summary Compensation Table Total for PEO ($) | Reported Value of Equity Awards(1) ($) | Equity Award Adjustments(2) ($) | Compensation Actually Paid to PEO ($) | |||||
| 2022 (George) | 1,656,403 | – | (6,314,736) | (4,658,333) | |||||
| 2022 (Knight) | 4,949,252 | (3,551,300) | (1,083,395) | 314,557 | |||||
| 2021 | 8,828,254 | (8,328,101) | (4,425,460) | (3,925,307) | |||||
| 2020 | 3,881,365 | (3,430,020) | 17,160,874 | 17,612,219 |
| (1) | The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year. |
INVITAE CORPORATION • 2023 Proxy Statement 37
| (2) | The amounts deducted or added in calculating the total average equity award adjustments for our PEOs are as follows: |
| Year | Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year ($) | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years ($) | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year ($) | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year ($) | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year ($) | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation ($) | Total Equity Award Adjustments ($) | ||||||||
| 2022 (George) | – | (599,883) | 40,690 | (3,419,670) | (2,335,874) | – | (6,314,736) | ||||||||
| 2022 (Knight) | 1,908,313 | (1,716,363) | – | (1,196,017) | (79,328) | – | (1,083,395) | ||||||||
| 2021 | 3,546,295 | (6,130,366) | – | (1,723,736) | (117,653) | – | (4,425,460) | ||||||||
| 2020 | 9,012,711 | 6,294,391 | 47,908 | 2,127,303 | (321,439) | – | 17,160,874 |
| The amounts in the following table represent the average of the amounts deducted and added to our NEOs’ total compensation as a group (excluding the CEO) for the applicable year for purposes of computing the “compensation actually paid” amounts appearing in the pay versus performance table: |
| Year | NEO Names | Average Reported Summary Compensation Table Total for Non-PEO NEOs ($) | Average Reported Value of Equity Awards ($) | Average Equity Award Adjustments(1) ($) | Average Compensation Actually Paid to Non- PEO NEOs ($) | ||||||
| 2022 | See footnote (c) | 2,529,338 | (1,555,725) | (1,352,365) | (378,752) | ||||||
| 2021 | See footnote (c) | 3,494,722 | (2,996,024) | (1,834,703) | (1,336,005) | ||||||
| 2020 | See footnote (c) | 3,798,621 | (3,448,684) | 8,462,236 | 8,812,173 |
| (1) | The amounts deducted or added in calculating the total average equity award adjustments are as follows: | |
| Year | NEO Names | Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year ($) | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Years ($) | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year ($) | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year ($) | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year ($) | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation ($) | Total Equity Award Adjustments ($) | |||||||||
| 2022 | See footnote (c) | 478,654 | (1,018,532) | – | (733,159) | (79,328) | – | (1,352,365) | |||||||||
| 2021 | See footnote (c) | 1,317,326 | (2,349,964) | 38,236 | (807,338) | (32,963) | – | (1,834,703) | |||||||||
| 2020 | See footnote (c) | 5,769,519 | 2,095,557 | 412,384 | 412,458 | (227,681) | – | 8,462,236 |
| (c) | The names of each of the NEOs included for purposes of calculating the average amounts in each applicable year are as follows: (i) for 2022, Thomas R. Brida, Robert L. Nussbaum, MD, and Yafei (Roxi) Wen; (ii) for 2021, Thomas R. Brida, Shelly D. Guyer, Kenneth D. Knight, Robert L. Nussbaum, MD, and Yafei (Roxi) Wen; and (iii) for 2020, Lee Bendekgey, Thomas R. Brida, Shelly D. Guyer, Kenneth D. Knight and Katherine A. Stueland. |
| (d) | The peer group used for this purpose is the S&P 500 Healthcare Index, our peer group used for purposes of Item 201(e) of Regulation S-K. |
| (e) | As required by Item 402(v) of Regulation S-K, we have determined that Cash Burn is the Company Selected Measure, as it is the most important financial performance measure (that is not otherwise required to be disclosed in the table) used to link compensation actually paid to our NEOs to company performance for the most recently completed fiscal year. |
Invitae’s compensation program is designed to attract and retain executives whose talents and contributions sustain long-term growth by aligning their interests with the drivers of stockholder returns and supporting their achievement of Invitae’s primary business goals. Invitae considers several performance measures to ensure executives are incentivized to accomplish these objectives, many of which are not presented in the pay versus performance table. The charts and descriptions below explain the relationship between the columns presented in the pay versus performance table.
INVITAE CORPORATION • 2023 Proxy Statement 38
The graph below shows our cumulative TSR over the three-year period ending with December 31, 2022 as compared to the S&P 500 Healthcare index which is the index used for purposes of our performance graph in our Annual Report on Form 10-K for the year ended December 31, 2022.
The chart below demonstrates that the “compensation actually paid” amounts shown for Dr. George and Mr. Knight and average “compensation actually paid” to the other NEOs is aligned with our cumulative TSR over the three years presented in the pay versus performance table. The alignment of compensation actually paid with our cumulative TSR over the period presented reflects that a significant portion of the compensation actually paid to Dr. George and Mr. Knight and to the other NEOs is comprised of equity awards. Moreover, our executive compensation philosophy and design is fundamentally based on a commitment to align pay and performance.
The chart below compares the “compensation actually paid” to our net losses over the three years presented in the pay versus performance table.
Our cash burn was $693.7 million in 2020, when$849.2 million in 2021 and $509.6 million in 2022. Dr. George’s “compensation actually paid” was approximately $17.6 million, ($3.9 million) and ($4.7 million) in the corresponding years (and Mr. Knight’s was approximately $0.3 million in 2022) and the average “compensation actually paid” to our CEO pay ratioother NEOs was 28approximately $8.8 million, ($1.3 million) and ($0.8 million) in each of those years, respectively. While we use numerous financial and non-financial performance measures for the purpose of evaluating performance for our compensation programs, we have determined that cash burn is the financial performance measure that, in our assessment, represents the most important performance measure (that is not otherwise required to 1, restricted stock units were valued at $16.17be disclosed in the table) used to link compensation actually paid to NEOs, for the most recently completed fiscal year, to our performance. We place significant emphasis on decreasing cash burn because it reflects strong performance and option awards at $10.04. Ifoperating efficiency in the 2021 CEO pay ratio were calculatedunderlying business, which is imperative for sustained long-term growth. A reconciliation of this non-GAAP financial metric to the closest GAAP equivalent is presented in Annex A.
INVITAE CORPORATION • 2023 Proxy Statement 39
The performance measures that we use in our executive compensation program are selected based on the closing priceobjective of our common stock on December 31, 2021, our CEO’s annual totalincentivizing NEOs to achieve long-term, sustainable growth in stockholder value. As required by Item 402(v) of Regulation S-K, we have identified the following financial performance measures as being the most important in linking actual compensation would be $4,144,191, and our median employee’s annual total compensation would be $143,877, and the ratio of our CEO’s annual total compensationpaid to executives to our median employee’s total annual compensation would be 29 to 1.performance.
Revenue Cash Burn Non-GAAP Gross Margin |
The following table summarizes the number of shares of common stock to be issued upon the exercise of outstanding options, warrants and rights granted to our employees, consultants and directors, as well as the number of shares of common stock remaining available for future issuance under our equity compensation plans as of December 31, 2021.2022.
| Name | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) | Weighted average exercise price of outstanding options, warrants and rights (b) | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) | ||||
| Equity compensation plans approved by security holders | 19,280,776 | (1) | $ 11.98 | 12,342,718 | (2) | ||
| Equity compensation plans not approved by security holders | — | — | — | ||||
| Total | 19,280,776 | $ 11.98 | 12,342,718 |
| Name | Number of securities to be issued upon exercise of outstanding options, warrants and rights (a) | Weighted average exercise price of outstanding options, warrants and rights (b) | Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in column (a)) | ||||
| Equity compensation plans approved by security holders | 14,436,920 | (1) | $8.49 | 14,774,629 | (2) | ||
| Equity compensation plans not approved by security holders | – | – | – | ||||
| Total | 14,436,920 | $8.49 | 14,774,629 |
| (1) | Excludes |
| (2) | Represents |
| The 2015 Stock Plan contains an “evergreen” provision, pursuant to which the number of shares of common stock reserved for issuance pursuant to awards under such plan shall be increased on the first day of each year beginning in 2016, equal to the lesser of (x) 4% of the number of shares of common stock outstanding on the last day of the immediately preceding fiscal year or (y) if our board of directors acts prior to the first day of the fiscal year, such lesser amount that our board of directors determines for purposes of the annual increase for that fiscal year. As of January 1, | |
| The ESPP contains an “evergreen” provision, pursuant to which the number of shares of common stock available for purchase under such plan shall be increased on the first day of each year beginning in 2016, equal to the lesser of (x) 1% of the number of shares of common stock outstanding on such date or (y) a lesser amount determined by our board of directors. As of January 1, |
INVITAE CORPORATION• 20222023 Proxy Statement 3440
The following table sets forth certain information as of April 8, 2022,10, 2023, which is the record date for the Annual Meeting (the “Record Date”), as to shares of our common stock beneficially owned by: (1) each person who is known by us to own beneficially more than 5% of our common stock, (2) each of our named executive officers listed in the Summary Compensation Table, (3) each of our directors and director nominees and (4) all of our current directors and executive officers as a group.
We have determined beneficial ownership in accordance with the rules of the SEC. Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the persons and entities named in the table below have sole voting and investment power with respect to all shares of common stock that they beneficially own, subject to applicable community property laws.
The percentage of our common stock beneficially owned is based on 229,193,795260,674,728 shares of common stock outstanding as of April 8, 2022,10, 2023, the Record Date for the Annual Meeting. In computing the number of shares of common stock beneficially owned by a person and the percentage ownership of that person, we deemed outstanding shares of common stock subject to options held by that person that are currently exercisable or exercisable, or RSUs that vest, in each case, within 60 days of April 8, 2022.10, 2023. We did not deem these shares outstanding, however, for the purpose of computing the percentage ownership of any other person.
Except as otherwise set forth in footnotes to the table below, the address of each of the persons listed below is c/o Invitae Corporation, 1400 16th Street, San Francisco, California 94103.
| Name and address of beneficial owner | Number of shares beneficially owned | Percentage of shares beneficially owned | |
| Named Executive Officers and Directors: | |||
| Sean E. George, Ph.D.(1) | 1,501,388 | * | |
| Yafei (Roxi) Wen(2) | 45,730 | * | |
| Shelly D. Guyer(3) | 264,432 | * | |
| Thomas R. Brida(4) | 179,927 | * | |
| Kenneth D. Knight(5) | 207,987 | * | |
| Robert L. Nussbaum, M.D.(6) | 273,929 | * | |
| Eric Aguiar, M.D.(7) | 37,400 | * | |
| Geoffrey S. Crouse(8) | 104,659 | * | |
| Christine M. Gorjanc(9) | 87,900 | * | |
| Kimber D. Lockhart(10) | 20,400 | * | |
| Chitra Nayak(11) | 58,733 | * | |
| All current executive officers and directors as a group ( 10 persons)(12) | 2,518,053 | 1.1% | |
| 5% Stockholders: | |||
| ARK Investment Management LLC(13) | 26,700,813 | 11.7% | |
| The Vanguard Group(14) | 19,445,884 | 8.5% | |
| Sumitomo Mitsui Trust Holdings, Inc. and affiliated entities(15) | 18,998,453 | 8.3% | |
| BlackRock, Inc. and affiliated entities(16) | 17,484,785 | 7.6% | |
| Casdin Capital, LLC and affiliated entities(17) | 12,203,669 | 5.3% |
| Name and address of beneficial owner | Number of shares beneficially owned | Percentage of shares beneficially owned | ||
| Named Executive Officers and Directors: | ||||
| Kenneth D. Knight(1) | 364,225 | * | ||
| Yafei (Roxi) Wen(2) | 150,082 | * | ||
| Thomas R. Brida(3) | 274,158 | * | ||
| Robert L. Nussbaum, MD(4) | 366,997 | * | ||
| Sean E. George, PhD(5) | 695,993 | * | ||
| Eric Aguiar, MD(6) | 102,600 | * | ||
| Geoffrey S. Crouse(7) | 152,859 | * | ||
| Christine M. Gorjanc(8) | 136,100 | * | ||
| Kimber D. Lockhart(9) | 73,100 | * | ||
| Chitra Nayak(10) | 108,600 | * | ||
| William H. Osborne | – | – | ||
| Randal W. Scott, PhD(11) | 190,750 | * | ||
| All current executive officers and directors as a group (11 persons)(12) | 1,919,471 | * | ||
| 5% Stockholders: | ||||
| ARK Investment Management LLC(13) | 27,072,844 | 10.4% | ||
| The Vanguard Group(14) | 22,587,955 | 8.7% | ||
| BlackRock, Inc. and affiliated entities(15) | 21,768,046 | 8.4% | ||
| Sumitomo Mitsui Trust Holdings, Inc. and affiliated entities(16) | 17,256,161 | 6.6% |
| * | Represents beneficial ownership of less than 1%. |
| (1) | Includes options to purchase |
| (2) | Includes |
| (3) | Includes options to purchase |
| (4) | Includes options to purchase |
| (5) | Includes options to purchase 8,050 shares of common stock that are exercisable within 60 days of April 10, 2023. |
INVITAE CORPORATION• 20222023 Proxy Statement 3541
| Includes options to purchase | |
| Includes options to purchase | |
| Includes options to purchase | |
| Includes options to purchase | |
| Includes options to purchase | |
| Includes (i) options to purchase | |
| Includes options to purchase | |
| According to Amendment No. | |
| (14) | According to Amendment No. |
| (15) | According to Schedule 13G filed on January 25, 2023 by BlackRock, Inc. (“BlackRock”), BlackRock has sole voting power with respect to 20,839,649 of the shares and sole dispositive power with respect to 21,768,046 of the shares on behalf of itself and the following subsidiaries: BlackRock Advisors, LLC, Aperio Group, LLC, BlackRock (Netherlands) B.V., BlackRock Institutional Trust Company, National Association, BlackRock Asset Management Ireland Limited, BlackRock Financial Management, Inc., BlackRock Asset Management Schweiz AG, BlackRock Investment Management, LLC, BlackRock Investment Management (UK) Limited, BlackRock Asset Management Canada Limited, BlackRock Investment Management (Australia) Limited, BlackRock Fund Advisors, and BlackRock Fund Managers Ltd. The principal address for BlackRock is 55 East 52nd Street, New York, NY 10055. |
| (16) | According to Amendment No. |
INVITAE CORPORATION• 20222023 Proxy Statement 3642
The audit committee operates under a written charter adopted by the board of directors. A link to the audit committee charter is available on our website at www.invitae.com.ir.invitae.com. All members of the audit committee meet the independence standards established by the NYSE.
In performing its functions, the audit committee acts in an oversight capacity and necessarily relies on the work and assurances of the Company’s management, which has the primary responsibility for financial statements and reports, and of the independent registered public accounting firm, who, in their report, express an opinion on the conformity of the Company’s annual financial statements with accounting principles generally accepted in the United States. It is not the duty of the audit committee to plan or conduct audits, to determine that the Company’s financial statements are complete and accurate and are in accordance with generally accepted accounting principles, or to assess or determine the effectiveness of the Company’s internal control over financial reporting.
Within this framework, the audit committee has reviewed and discussed with management the Company’s audited financial statements as of and for the year ended December 31, 2021.2022. The audit committee has also discussed with the independent registered public accounting firm, Ernst & Young LLP, the matters required to be discussed by Auditing Standard No. 1301, Communications with Audit Committees, issued by the Public Company Accounting Oversight Board and the SEC. In addition, the audit committee has received the written disclosures and the letter from the independent registered public accounting firm required by applicable requirements of the Public Company Accounting Oversight Board regarding the independent registered public accounting firm’s communications with the audit committee concerning independence, and has discussed with the independent registered public accounting firm the independent registered public accounting firm’s independence.
Based upon these reviews and discussions, the audit committee recommended to the board of directors that the audited financial statements be included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021.2022.
Audit Committee
Christine M. Gorjanc, Chair
Geoffrey S. Crouse
Kimber D. Lockhart
William H. Osborne
INVITAE CORPORATION• 20222023 Proxy Statement 3743
On February 28, 2023, we entered into separate, privately negotiated purchase and exchange agreements (collectively, the “Exchange Agreements”) with respect to (a) the issuance of approximately $275.3 million aggregate principal amount of our Certificate4.5% Series A Convertible Senior Secured Notes due 2028 (the “Series A Notes”) and 14,219,859 shares (the “New Shares”) of Incorporationour common stock, in exchange for approximately $305.7 million aggregate principal amount of our currently outstanding 2.0% Convertible Senior Notes due 2024 (the “Old Notes”) and (b) $30.0 million aggregate principal amount of our new 4.5% Series B Convertible Senior Secured Notes due 2028 (the “Series B Notes” and, together with the Series A Notes, the “Notes”) for cash. The Notes were issued pursuant to, Increaseand are governed by, an indenture (the “Indenture”), dated as of March 7, 2023 (the “Closing Date”), among Invitae, the Numberguarantors parties thereto and U.S. Bank Trust Company, National Association, as trustee and collateral agent. Based on the initial conversion price of Authorized Shares$2.58, the Notes will be initially convertible into an aggregate of Common Stock
Our Restated Certificate currently authorizes us to issue a total of 400,000,000118,316,667 shares of common stock, $0.0001 par value per share. On April 1, 2022,and after careful consideration, our boardtaking into account the maximum number of directors unanimously approvedadditional shares issuable in certain circumstances as described in the Indenture, an amendmentaggregate of 141,979,975 shares of common stock.
The Indenture also provides for the issuance of warrants to the Restated Certificate to authorize an additional 200,000,000purchase shares of common stock (the “Amendment”“Warrants”), subject to stockholder approval. Our board of directors has unanimously determined that the Amendment is advisable and in the best interestsconnection with (i) redemption of the Company and our stockholders, and, in accordance with the General Corporation LawNotes or (ii) acceleration of the StateNotes following the occurrence of Delaware, hereby seeks approvalan event of default under the Indenture as a result of the Amendmentfailure by our stockholders.
Our board of directors is proposingus to settle any conversion. Any Warrants issued will cover the Amendment, in substantially the form attached hereto as Appendix A, to increase thesame number of authorized shares of our common stock from 400,000,000 shares to 600,000,000 shares. Of the 400,000,000 shares of common stock currently authorized byunderlying, and at an exercise price equal to the Restated Certificate and asconversion price of, the Record Date, 229,193,795redeemed or prepaid Notes.
Conversion of Series A Notes, or exercise of any Warrants issued in respect of the Series A Notes, into shares of common stock, were issued and outstanding which excludes, ashowever, could result in the issuance of December 31, 2021: (i) 3,034,307shares of common stock in excess of the limitations imposed by Section 312.03(c) of the NYSE Listed Company Manual (the “NYSE Limitations”). The number of shares of common stock issuable upon such conversion or exercise is subject to further increase pursuant to the anti-dilution adjustment provisions under the Indenture in respect of certain specified dilutive issuances within two years following the issuance of the Series A Notes or any Warrants issued in respect of the Series A Notes. Because NYSE rules state that, in certain circumstances, an issuer is required to obtain stockholder approval prior to the issuance of common stock in any transaction or series of transactions if (i) the shares of common stock will have upon issuance voting power equal to 20% or more of the voting power outstanding before the issuance of common stock or (ii) the number of shares of common stock to be issued will upon issuance equal 20% or more of the number of shares of common stock outstanding before the issuance of common stock, the Series A Notes and any Warrants issued in respect of the Series A Notes currently limit the issuance of common stock to the number of shares equal to (a) 19.9% of our common stock outstanding as of the Closing Date, minus (b) the number of the New Shares, plus (c) the number of shares of common stock that would have been issuable under the Old Notes at a maximum conversion rate thereunder, which is equal to 49,396,519 shares of our common stock (the “NYSE Share Cap”).
Issuance of shares of common stock in excess of the applicable NYSE Limitations upon conversion of Series B Notes, or exercise of any Warrants issued in respect of the Series B Notes, into shares of common stock options outstanding under our equity incentive plans, with a weighted-averageis exempted from the stockholder approval requirement, so long as the conversion price of the Series B Notes exceeds the “Minimum Price” (as defined in Section 312.04 of the NYSE Listed Company Manual). The Indenture has anti-dilution adjustment provisions in respect of certain specified dilutive issuances within two years following the issuance of the Series B Notes which could have the effect of reducing the conversion price of the Series B Notes or the exercise price of $11.98 per share; (ii) 16,246,742any Warrants issued in respect of the Series B Notes below the “Minimum Price”. In order to ensure compliance with the “Minimum Price” requirement during such two year period for purposes of the applicable NYSE Limitations, the Indenture and the Warrants prohibit, until such time that we obtain stockholder approval, us from entering into any transaction that would cause an adjustment to the number of shares of common stock issuable upon vestingconversion of RSU under our equity incentive plans; (iii) 10,242,337the Series B Notes or upon exercise of any Warrants issued in respect of the Series B Notes to exceed the applicable NYSE Limitations.
The Indenture also contains a conversion blocker that prohibits the conversion of any Notes or exercise of any Warrants into shares of common stock, available for future issuance under our 2015 Stock Incentive Plan; (iv) 2,099,126if upon such conversion or exercise, such holder would beneficially own in excess of 4.9% of the total number of shares of common stock available for future issuance under our Employee Stock Purchase Plan;then issued and (v) 10,238,013outstanding (the “Beneficial Ownership Blocker”). However, the largest holder of the Notes, as of the Closing Date, owned Notes that, on an as-converted basis based on the initial conversion price of the Notes and disregarding the Beneficial Ownership Blocker, would be convertible into more than 20% of the total number of shares of common stock that may be issuablethen issued and outstanding. Therefore, the conversion of the Notes or exercise of the Warrants issued in connection with indemnification hold-backs and contingent consideration related to our acquisitions. Also excluded are (i) 9,124,629 and 2,281,157 additionalrespect of the Notes into shares of common stock available for future issuance under our 2015 Stock Incentive Plan and our Employee Stock Purchase Plan, respectively, as of January 1, 2022, (ii) shares that may be issuable in the future in connection with our 2.00% Convertible Senior Notes due 2024, (iii) shares that may be issuable in the future in connection with our 1.50% Convertible Senior Notes due 2028, and (iv) shares that may be issued pursuant to our Sales Agreement with Cowen and Company, LLC, dated May 4, 2021. No changes to the Restated Certificate are being proposed with respect to the number of authorized shares of preferred stock. Other than the proposed increase in the number of authorized shares of common stock, the Amendment is not intended to modify the rights of existing stockholders inby such noteholder or any respect.
Our board of directors believes the Amendment is advisable and in the best interestsother purchaser or holder of the Company and our stockholders. Invitae is endeavoring to fundamentally change the way healthcare is delivered, using genetic information as a basis for many decisions that impact human life and wellness. Progress toward this goal has been substantial in the decade since the Company was founded, but we believe more investment and growth are ahead of us as we build out a platform that is capable of leading and supporting this fundamental change.
ApprovalNotes with sufficient amount of the Amendment would make available for future issuanceNotes and/or Warrants could potentially constitute a sufficient number“change of authorized sharescontrol”, which is subject to stockholder approval under Section 312.03(d) of common stock to provide us with appropriate flexibility to issue shares for future corporate needs. The additional authorized shares would provide us with increased financing and capital raising flexibility to support our need for additional capital. An increase in capital would support the growth of our business and could be used for other business and financial purposes that our board of directors deems are in the Company’s best interest, including the acquisition of other companies, businesses or products in exchange for common stock, attraction and retention of employees through the issuance of additional securities under our equity incentive plans, and implementation of stock splits and issuance of dividends in the future.NYSE Listed Company
Without an increase in the number of authorized shares of common stock, the Company may be constrained in its ability to raise capital to support our business objectives, and the Company may lose important business opportunities, including to competitors, which could adversely affect our financial performance and growth.
INVITAE CORPORATION• 20222023 Proxy Statement 3844
Manual. For the avoidance of doubt, the Beneficial Ownership Blocker shall remain in place until the maturity date of the Notes.
The additional authorizedpreceding description is a summary of certain principal terms of the Notes and Warrants. While we believe that the summary above describes the material terms of the Notes and Warrants necessary for you to make a voting decision for the purposes of this Proposal 2, it may not contain all of the information that is important to you and is qualified in its entirety by reference to our Current Reports on Form 8-K filed with the SEC on March 1, 2023 and March 8, 2023, which are incorporated herein by reference, and to the Indenture, the Notes, the form of Warrant, and the form of Exchange Agreements, which are included as exhibits to such Current Reports on Form 8-K. We encourage you to read the Indenture, the Notes, the form of Warrant, and the form of Exchange Agreements in their entirety.
We are asking our stockholders to consider and vote on a proposal to approve the issuance of shares of common stock would enablepursuant to the conversion of the Notes and/or exercise of any Warrants issued in respect of the Notes in excess of the limitation imposed by the NYSE Share Cap, and related change of control. Approval of Proposal 2 will allow us to act quicklyissue and deliver the number of shares of common stock upon conversion of the Notes and/or exercise of any Warrants issued in responserespect of the Notes in excess of the respective limitations under Section 312.03 of the NYSE Listed Company Manual.
Our common stock is listed on the NYSE and, as a result, we are subject to capital raisingcertain NYSE listing rules and other corporate opportunities that may arise (as described above), in most cases withoutregulations. Pursuant to Section 312.03(c) of the necessity of holding a special stockholders’ meeting and obtaining furtherNYSE Listed Company Manual, subject to certain exceptions, stockholder approval beforeis required prior to the issuance of common stock, could proceed, except as may be required by applicable law or of securities convertible into or exercisable for common stock, in any transaction or series of related transactions if: (1) the listing rulescommon stock has, or will have upon issuance, voting power equal to or in excess of 20% of the NYSE, or any other stock exchange on which our securities may be listed.
Other than issuances pursuant to equity incentive plans (or upon the exercise of securities issued pursuant to equity incentive plans), or as otherwise described above, as of the date of this Proxy Statement, we have no current plans, arrangements or understandings regardingvoting power outstanding before the issuance of any additionalsuch stock or of securities convertible into or exercisable for common stock or (2) the number of shares of common stock that wouldto be authorizedissued is, or will be upon issuance, equal to or in excess of 20% of the number of shares of common stock outstanding before the issuance of the common stock or of securities convertible into or exercisable for common stock. In addition, pursuant to this proposal,Section 312.03(d) of the NYSE Listed Company Manual, stockholder approval is required for any issuance that will result in a change of control of the issuer. We are seeking stockholder approval of the issuance of shares of common stock in excess of the applicable NYSE Limitations, and thererelated change of control.
We are no negotiations pending with respectseeking stockholder approval of the issuance of shares of common stock pursuant to the issuance thereof forconversion of the Notes and/or exercise of any purpose. However,Warrants issued in respect of the Notes, and related change of control, under Section 312.03(c) and Section 312.03(d) of the NYSE Listed Company Manual. We are seeking stockholder approval to make such issuances because we reviewwould like the ability to settle conversions of the Notes and evaluate potential capital raising activities, transactionsexercises of the Warrants in shares of our common stock and other corporate opportunities on an ongoing basis to determineavoid additional financial obligations we will face if any such actions wouldwe do not receive stockholder approval. We believe this settlement method will be in our best interests and the best interests of the Company and our stockholders.
Our management has recently communicated its goals to decrease cash burn, enhance operational excellence and chart a pathway to positive cash flow in the coming years. Our management believes the availability of additional authorized common stock for issuance, above that envisionedstockholders at the time of conversion or exercise. Because the company’s initial public offering, allows forissuance by us of a number of shares exceeding the flexibilityapplicable NYSE Limitations or the issuance of shares that may result in a change of control upon the conversion of the Notes and/or exercise of the Warrants without stockholder approval may result in a violation of Section 312.03(c) and Section 312.03(d) of the NYSE Listed Company Manual, we are seeking stockholder approval pursuant to actSection 312.03(c) and Section 312.03(d) of the NYSE Listed Company Manual.
INVITAE CORPORATION • 2023 Proxy Statement 45
While our board of directors believes that the NYSE Proposal is advisable and in the best interest of stockholder value when opportunities arise.Invitae and our stockholders, you should consider the following factors, together with the other information included in this Proxy Statement, in evaluating this proposal.
Dilution. The issuance of Additional Authorized Shares
The additional authorized shares of common stock, if and when issued, would be part of the existing class of common stock and would have the same rights and privileges as the shares of common stock currently outstanding. Stockholders do not have preemptive rights with respect to our common stock. Therefore, should our boardwhich are the subject of directors determine to issue additional shares of common stock, existing stockholders would not have any preferential rights to purchase such sharesthis proposal will result in order to maintain their proportionate ownership thereof.
Thean increase in the number of authorized shares of common stock will not have any immediate effect on the rights ofoutstanding. This means that our existing stockholders. Our boardstockholders will own a smaller ownership interest in Invitae as a result of directors willsuch issuance and therefore have less ability to influence significant corporate decisions requiring stockholder approval.
Market Effects. Holders of the authorityNotes who receive common stock upon conversion of the Notes and/or exercise of any Warrants issued in respect of the Notes may be able to issue the additionalsell these shares of common stock without requiring future stockholder approvalpursuant to a registration statement or any applicable exemption under the Securities Act of such issuances, except1933, as may be required by applicable lawamended, or the listing rules of the NYSE or any other stock exchange on which our securities may be listed. The issuance of additional sharespromulgated thereunder, including Rule 144, if applicable. If significant quantities of common stock will decrease the relative percentage of equity ownership of our existing stockholders, thereby diluting the voting power of their common stock, and, depending on the price at which the additional shares are issued, may also be dilutive to any future earnings per share of our common stock.
Although we have no immediate plans to do so, we could use the additional authorized shares of common stock for potential strategic transactions, including, among other things, acquisitions, strategic partnerships, joint ventures, restructurings, divestitures, business combinations and investments. We cannot provide assurances that any such transactions would be consummated on favorable termssold, or at all,if it is perceived that they would enhance stockholder value or that they would not adversely affect our business ormay be sold, the trading price of our common stock. Any such transactions may require us to incur non-recurring or other charges and may pose significant integration challenges and/or management and business disruptions, any of which could materially and adversely affect our business and financial results. The authorization of additional shares of common stock could also have an anti-takeover effect, in that the additional shares could be issuedadversely affected.
If stockholder approval our board of directors could sell shares of our common stock inis not obtained at the Annual Meeting, we will seek stockholder approval at a private transaction to purchasers who would oppose a takeover attempt or favor our current board of directors. Although this proposal to increase the number of authorized shares of common stock has been prompted by business and financial considerations and not by any current or threatened hostile takeover attempt, stockholders should be aware that approval of this proposal could facilitate future attempts by the Company to oppose changes in control of the Company and to perpetuate our then-current management, including the opposition of transactions in which the stockholders might otherwise receive a premium for their shares over then-current market prices.
INVITAE CORPORATION • 2022 Proxy Statement 39
If the Amendment is approved by our stockholders, the Amendment will become effective upon the filing of a certificate of amendment with the Delaware Secretary of State, which filing is expected to occur promptlyspecial meeting held as soon as possible after the Annual Meeting. If the Amendmentstockholder approval is not approved by our stockholders,obtained prior to September 30, 2023, the Restated Certificate will notNotes that would be amended and the number of authorizedissuable upon conversion into shares of common stock representing more than NYSE Share Cap will remain unchanged. The affirmative vote ofbe convertible into cash. If we do not have cash to satisfy these requirements, we may be in default under the holders of a majority of the shares of our common stock issued and outstanding is required to approve the Amendment. As a result, abstentions will have the effect of a vote “AGAINST” this proposal.Notes.
  | THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE APPROVAL OF, |
INVITAE CORPORATION• 20222023 Proxy Statement 4046
Section 14A of the Securities Exchange Act of 1934 (the “Exchange Act”) requires U.S. public companies to provide stockholders with the opportunity to vote to approve, on a non-binding, advisory basis, the compensation of our named executive officers as disclosed in this Proxy Statement in accordance with the compensation disclosure rules of the SEC. At the Company’s 2020 annual meeting of stockholders, a majority of our stockholders voted in favor of holding an advisory vote to approve the compensation of the Company’s named executive officers every year. Our board of directors considered this voting result and decided to hold the vote every year, until the next non-binding advisory vote on the frequency of future advisory votes on the compensation of the Company’s named executive officers, which is expected to be at the 2026 annual meeting of stockholders.
As described in detail under the heading “Executive Compensation — Compensation Discussion and Analysis,” our executive compensation programs are designed to attract and retain our named executive officers, who are critical to our success. Under these programs, our named executive officers are rewarded for the achievement of annual and long-term corporate objectives, and the creation of increased stockholder value. Please read the Compensation Discussion and Analysis for additional details about our executive compensation programs, including information about the 20212022 compensation of our named executive officers.
Each year since 2020, we sought, and received, approval for our executive compensation program. In addition, in 2020, we sought, and received, approval to hold a “say-on-pay” vote each year. Accordingly, we are again asking our stockholders to indicate their support for our named executive officer compensation as described in this Proxy Statement. This proposal gives our stockholders the opportunity to express their views on our named executive officers’ compensation. This vote is advisory, which means that the vote on executive compensation is not binding on us, our board of directors or the compensation committee of the board. This vote is not intended to address any specific item of compensation, but rather the vote relates to the compensation of our named executive officers as a whole, as described in this Proxy Statement in accordance with the compensation disclosure rules of the SEC. Accordingly, we will ask our stockholders to vote for the following resolution at the Annual Meeting:
“RESOLVED, that the Company’s stockholders approve, on a non-binding advisory basis, the compensation of the named executive officers, as disclosed in the Company’s Proxy Statement for the 20222023 Annual Meeting of Stockholders pursuant to the compensation disclosure rules of the Securities and Exchange Commission, including the Compensation Discussion and Analysis, the Summary Compensation Table and the other related tables and disclosure.”
 | THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE APPROVAL, ON A NON-BINDING ADVISORY BASIS, OF THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS. |
INVITAE CORPORATION• 20222023 Proxy Statement 4147
The audit committee has appointed Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022.2023. Ernst & Young LLP has audited our financial statements since 2013. Representatives of Ernst & Young LLP are expected to attend the virtual Annual Meeting. They will have an opportunity to make a statement, if they desire to do so, and will be available to respond to appropriate questions.
The following table sets forth the fees billed by Ernst & Young LLP for audit and other services rendered:
| Year ended December 31, | |||||
| (In thousands) | 2021 ($) | 2020 ($) | |||
| Audit Fees(1) | 3,249 | 2,545 | |||
| Audit-related Fees(2) | 1,696 | 1,442 | |||
| Tax Fees | — | — | |||
| All Other Fees(3) | — | 90 | |||
| 4,945 | 4,077 | ||||
| Year ended December 31, | ||||
| (In thousands) | 2022 ($ in millions) | 2021 ($ in millions) | ||
| Audit Fees(1) | 3,637 | 3,249 | ||
| Audit-related Fees(2) | 795 | 1,696 | ||
| Tax Fees | – | – | ||
| All Other Fees(3) | – | – | ||
| 4,432 | 4,945 | |||
| (1) | Audit fees include fees and out-of-pocket expenses, whether or not yet invoiced, for professional services provided in connection with the audit of our annual financial statements and review of our quarterly financial statements, as well as services in connection with regulatory filings or engagements. |
| (2) | Audit-related fees consist of fees incurred for procedures in connection with acquisitions and consultation regarding financial accounting and reporting matters. |
| (3) | All other fees consist of the cost of our subscription to an accounting research tool provided by Ernst & Young LLP. |
In connection with our initial public offering, our audit committee established a policy to pre-approve all audit and permissible non-audit services provided by our independent registered public accounting firm. All of the services provided were pre-approved to the extent required. During the approval process, the audit committee considers the impact of the types of services and the related fees on the independence of the independent registered public accounting firm. The services and fees must be deemed compatible with the maintenance of that firm’s independence, including compliance with rules and regulations of the SEC. Throughout the year, the audit committee will review any revisions to the estimates of audit and non-audit fees initially approved.
Stockholder ratification of the selection of Ernst & Young LLP as our independent registered public accounting firm is not required by our Bylaws or otherwise. However, our board of directors is submitting the selection of Ernst & Young LLP to the stockholders for ratification as a matter of good corporate practice. If the stockholders fail to ratify the selection, the audit committee will reconsider whether or not to retain Ernst & Young LLP. Even if the selection is ratified, the audit committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if the audit committee determines that such a change would be in the best interests of our Company and our stockholders.
 | THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE RATIFICATION OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM. |
INVITAE CORPORATION• 20222023 Proxy Statement 4248
In accordance with SEC rules, we have set forth below a stockholder proposal, along with a supporting statement, exactly as submitted by James McRitchie. Mr. McRitchie has notified us that he is the beneficial owner of 130 shares of Invitae’s common stock and intends to present the following proposal at the 2022 Annual Meeting. Mr. McRitchie’s address is 9295 Yorkship Court, Elk Grove, CA 95758. The stockholder proposal will be required to be voted upon at the 2022 Annual Meeting only if properly presented. The stockholder proposal and supporting statement is shown below and outlined by a box to distinguish it from statements of Invitae. The graphic below was submitted as part of the stockholder proposal.
Stockholder Proposal and Supporting Statement – Proposal 5 – Elect Each Director Annually
RESOLVED: Invitae Corp (“Company”) shareholders ask that our Company take all the steps necessary to reorganize the Board of Directors into one class with each director subject to election each year for a one-year term.
Supporting Statement: Arthur Levitt, former Chairman of the Securities and Exchange Commission said, “In my view it’s best for the investor if the entire board is elected once a year. Without annual election of each director shareholders have far less control over who represents them.”
Almost 90% of S&P 500 and Fortune 500 companies have adopted this vital reform. Annual elections are widely viewed as a best practice. Most investors believe Annual election of each director makes directors more accountable, thereby improving performance and increasing company value.
Shareholder resolutions on this topic won 16 of 18 votes at companies in 2019, 2020, and 2021, most by a wide margin.
According to BlackRock, “Directors should be elected annually to discourage entrenchment and allow shareholders sufficient opportunity to exercise their oversight of the board.” Vanguard generally votes for proposals to declassify an existing board and votes against management or shareholder proposals to create a classified board.
According to Equilar, a trusted leader for corporate leadership data:
A classified board creates concern among shareholders because poorly performing directors may benefit from an electoral reprieve. Moreover, a fraternal atmosphere may form from a staggered board that favors the interests of management above those of shareholders. Since directors in a declassified board are elected and evaluated each year, declassification promotes responsiveness to shareholder demands and pressures directors to perform to retain their seat. Notably, proxy advisory firms ISS and Glass Lewis both support declassified structures.
Consider our Company’s overall corporate governance: We cannot call special meetings or act by written consent and certain amendments require a supermajority.
Our Company’s bioscience is second to none. Our corporate governance should meet the same high standards.
Enhance Shareholder Value, Vote FOR Elect Each Director Annually – Proposal 5
INVITAE CORPORATION • 2022 Proxy Statement 43
Invitae’s Statement in Opposition to Proposal 5
Our board of directors recommends a vote AGAINST Proposal 5
Invitae’s board of directors has carefully considered the stockholder proposal seeking to declassify the board and require the annual election of all of Invitae’s directors and believes that its implementation would undermine our ability to act in the long-term best interest of our stockholders. The board believes that our classified board structure benefits all stockholders and better protects long-term stockholder value. Accordingly, our board of directors unanimously recommends a vote AGAINST this proposal.
Long-Term Focus, Stability and Continuity
We are committed to strong corporate governance, and our board regularly reviews our governance structure, including our classified board. Our board is divided into three classes, with each class serving a three-year term. We believe the longer term encourages our directors to make decisions in the long-term interest of Invitae and our stockholders. In contrast, annual election of all directors can, in some cases, lead to short-term focus or a concentration on only immediate results, which can discourage or impair long-term investments, improvements and initiatives.
Invitae’s classified board structure also creates stability and continuity on the board of directors and ensures that, at any given time, the board of directors is comprised of experienced directors who are familiar with our business, strategic goals, history and culture. We believe our current three-year terms are tailored to enable our existing and future directors to develop substantive knowledge about our specific operations and goals, which better positions them to make long-term strategic decisions that are in the best interest of our stockholders. If our board of directors were to be declassified, it could be replaced in a single year with directors who are unfamiliar with Invitae’s business, strategic goals, history and culture. In contrast, a classified board structure allows for orderly change alongside continuity as new directors with fresh perspectives interact and work with experienced directors.
Enhancing Director Independence
We believe that three-year terms for our directors ensure that our board as a whole is able to take a longer-term view with respect to Invitae and our business, thereby strengthening our non-management directors’ independence from special interest groups or other parties whose short-term goals may not be in the best interests of all of our stockholders. A classified board structure also assists us in attracting and retaining highly qualified directors who are willing to commit the time and resources necessary to understand our operations, strategies and competitive environment. We believe that agreeing to serve a three-year term demonstrates a nominee’s commitment to us and our strategic growth and success over the long term.
Provides for Accountability to Stockholders
All directors, regardless of the length of their term, have a fiduciary duty under the law to act in a manner they believe to be in the best interests of Invitae and all of our stockholders. The classified board structure still provides for accountability to stockholders. At each annual meeting, Invitae’s stockholders have the opportunity to evaluate and elect approximately one-third of the board.
Protects Stockholder Value
The classified board reduces Invitae’s vulnerability to certain potentially abusive takeover tactics. Because only one-third of the directors are elected at any annual meeting of stockholders, it is impossible to elect an entire new board of directors or even a majority of the board of directors at a single meeting. Incumbent directors always represent a majority of the board of directors and are in a position to negotiate with activists while protecting the interests of all stockholders.
A classified board does not preclude a takeover, but rather encourages potential acquirers to initiate arms-length negotiations with seasoned directors and provides our board of directors with the time and flexibility necessary to evaluate the adequacy and fairness of a proposed offer, consider alternative methods of maximizing stockholder value, protect stockholders against abusive tactics during a takeover process, and, as appropriate, negotiate the best possible return for all stockholders.
Declassification of our board of directors would undercut these benefits and could make us a target for unsolicited hostile overtures from investor groups focusing on short-term financial gains. In particular, in recent years, hedge funds and other activist investors have increasingly used the threat of a proxy fight to pressure boards to take actions that we believe produce short-term gains at the expense of strategies designed to achieve meaningful long-term stockholder value. We believe our classified board structure to be an effective means of protecting long-term stockholder interests against these types of abusive tactics.
Prevalence
We believe the prevalence of classified boards is more common in peer companies in our industry and with a market capitalization similar to ours than in larger companies. Our board of directors believes that maintaining our classified board not only provides the benefits described above, but is also consistent with the governance approach adopted by similar companies.
Classified boards remain significantly more common among technology and life sciences companies in the Silicon Valley 150 (SV 150) than among the S&P 100 companies, with 83.7% of Invitae’s peer group in the SV 150 having a classified board as of the 2021 proxy season. 52.1% of the SV 150 had a classified board, compared to 3% of the S&P 100. As the below graph illustrates, declassifying boards has been a trend among the largest public companies, but not among Silicon Valley companies. This reflects the reality that the takeover defense of a classified board is less compelling for some larger companies due to their size and the dispersion of their stockholders.
INVITAE CORPORATION • 2022 Proxy Statement 44
This data was obtained from page 35 of Fenwick & West LLP’s “Corporate Governance, Practices and Trends; A Comparison of Large Public Companies and Silicon Valley Companies – 2021 Proxy Season” (http://fenwick.com/corporategovernance) authored by Partner Dave A. Bell and Counsel Ron C. Llewellyn, published on January 12, 2022. The 2021 Fenwick – Bloomberg Law SV 150 List utilized on page 35 and throughout the report ranks the largest public technology and life sciences companies in Silicon Valley by revenue.
Summary
Our stockholders should be aware that this proposal is simply a request that our board of directors take the necessary steps to elect directors annually. Declassification of the board of directors requires an amendment to our Amended and Restated Bylaws, which must be adopted pursuant to the procedures set forth therein. A vote in favor of this proposal, therefore, would constitute a recommendation that the board of directors initiate this amendment process. For all of the reasons stated above, however, the board does not believe that such amendment is in the best interests of our stockholders.
After careful consideration of this proposal, the board of directors has determined that continuation of our classified board structure is appropriate and in the best long-term interests of Invitae and our stockholders. The board believes that the benefits of a classified board structure do not come at the expense of accountability and that the long-term focus, stability, enhanced director independence, and takeover protections provided by a staggered board structure are appropriate for Invitae and contribute to the success of Invitae for the benefit of our stockholders.
 |
INVITAE CORPORATION • 2022 Proxy Statement 45
Section 16(a) of the Exchange Act requires our executive officers and directors, and persons who own more than 10% of a registered class of our equity securities, to file reports of ownership on Forms 3, 4 and 5 with the SEC. These persons are required to furnish us with copies of all Forms 3, 4 and 5 they file. Based solely on our review of the copies of such forms we have received and written representations from certain reporting persons that they filed all required reports, we believe that all of our executive officers, directors and greater than 10% stockholders complied on a timely basis with all Section 16(a) filing requirements applicable to them with respect to transactions during 20212022 except as follows:
Dr. Nussbaum filed a Form 4 on August 20, 2021 with respect to an acquisition that was required to be filed by January 5, 2017. Ms. Guyer filed a Form 4 on May 20, 2021 with respect to an acquisition that was required to be filed by May 10, 2021.Wen, Mr. Brida, Dr. George and Dr. Nussbaum Mr. Brida, Ms. Guyer and Ms. Katherine A. Stueland each filed a Form 4 on March 17, 2021, each with respect to an acquisition16, 2022 that was required to be filed by March 16, 2021.15, 2022, and Mr. Knight filed a Form 4 on March 21, 2022 that was required to be filed by March 15, 2022.
To be considered for inclusion in the Company’s proxy statement for the 20232024 annual meeting of stockholders, stockholder proposals must be received by the Secretary of the Company no later than December 22, 2022.27, 2023. Proposals should be sent to our Secretary at Invitae Corporation, 1400 16th Street, San Francisco, California 94103. These proposals also must comply with the stockholder proxy proposal submission rules of the SEC under Rule 14a-8 of the Exchange Act. Proposals we receive after that date will not be included in the proxy statement.
Our Bylaws provide a proxy access provision stating that stockholders who meet the requirements set forth in our Bylaws may under certain circumstances include a specified number of director nominees in our proxy materials. Under the provision, eligible stockholders, or a group of up to 20 stockholders, owning at least 3% of our outstanding shares of common stock continuously for at least three years, may nominate and include in our annual meeting proxy materials a limited number of director nominees constituting up to the greater of (i) two directors or (ii) 20% of the board of directors (rounded down to the nearest whole number), subject to certain limitations and provided that the stockholders and nominees satisfy the requirements specified in our Bylaws. To be timely, our Bylaws provide that we must have received any proxy access nominations not more than 150 days nor less than 120 days prior to the anniversary of the date the proxy statement was provided to the stockholders in connection with preceding year’s annual meeting of stockholders. For the 20232024 annual meeting of stockholders, notice of any proxy access director nominations must be received by our Secretary at the above address between November 22, 202227, 2023 and December 22, 2022.27, 2023. Please refer to our Bylaws for a complete description of the proxy access requirements.
Our Bylaws also establish advance notice procedures for stockholders who wish to nominate an individual for election as a director or to present a proposal at the 20232024 annual meetingof stockholders but do not intend for the nomination or the proposal to be included in our proxy statement. A director nomination or stockholder proposal not included in the proxy statement for the 20232024 annual meeting of stockholders will not be eligible for presentation at the meeting unless the stockholder gives timely notice of the nomination or proposal in writing to our Secretary at the above address. To be timely, our Bylaws provide that we must have received the stockholder’s notice not more than 120 days nor less than 90 days prior to the anniversary of the date the proxy statement was provided to the stockholders in connection with preceding year’s annual meeting of stockholders. For the 20232024 annual meeting of stockholders, notice must be received between December 22, 202227, 2023 and January 21, 2023.26, 2024. Any such notice must contain the information and conform to the requirements specified in our Bylaws and must be a proper subject for stockholder action under applicable law.In addition to satisfying the applicable advance notice procedures in our Bylaws, stockholders who intend to solicit proxies in support of director nominees other than our nominees for the 2024 annual meeting of stockholders must provide notice that sets forth the information required by Rule 14a-19 under the Exchange Act. Notice must be delivered in writing to our Secretary at the above address no later than April 6, 2024.
INVITAE CORPORATION• 20222023 Proxy Statement 4649
Our board of directors does not know of any other business that will be presented at the Annual Meeting. If any other business is properly brought before the Annual Meeting, the proxy holders will vote in accordance with their judgment unless you direct them otherwise. Whether or not you intend to attend the Annual Meeting, we urge you to vote by Internet or telephone.
By Order of the Board of Directors
Thomas R. Brida
General Counsel, Chief Compliance Officer and Secretary
San Francisco, California
April 21, 202219, 2023
Stockholders may make a request for our Annual Report on Form 10-K for the year ended December 31, 20212022 in writing to our Secretary, Invitae Corporation, 1400 16th Street, San Francisco, California 94103. We will also provide copies of exhibits to our Annual Report on Form 10-K, but will charge a reasonable fee per page to any requesting stockholder. The request must include a representation by the stockholder that, as of April 8, 2022,10, 2023, the stockholder was entitled to vote at the Annual Meeting. Our Annual Report on Form 10-K and exhibits are also available at www.invitae.com.ir.invitae.com.
INVITAE CORPORATION• 20222023 Proxy Statement 4750
Our board of directors is soliciting your proxy to vote at the Annual Meeting, including at any adjournments or postponements of the meeting. This year’s Annual Meeting will be held virtually. You are invited to attend the Annual Meeting via live audio webcast to vote electronically on the proposals described in this Proxy Statement. However, you do not need to attend the meeting to vote your shares. Instead, you may follow the instructions below to submit your proxy by Internet or telephone.
In accordance with the rules of the SEC, we have opted to furnish proxy materials, including this Proxy Statement and our Annual Report, to our stockholders by providing access to such documents on the Internet instead of mailing printed copies. Accordingly, we are sending the Notice to our stockholders of record and beneficial stockholders as of April 8, 2022,10, 2023, the Record Date. Stockholders are encouraged to vote and submit proxies in advance of the Annual Meeting by Internet or telephone as early as possible to avoid processing delays.
We do not expect any other items of business because the deadline for stockholder proposals and nominations has already passed. Nonetheless, in case there is an unforeseen need, the accompanying proxy gives discretionary authority to the persons named on the proxy with respect to any other matters that might be properly brought before the meeting. Those persons intend to vote the proxy in accordance with their best judgment.
Stockholders of record at the close of business on the Record Date, April 8, 2022,10, 2023, may vote at the Annual Meeting. Each stockholder is entitled to one vote for each share of the Company’s common stock held as of the Record Date.
A list of stockholders of record entitled to vote at the Annual Meeting will be available for examination by any stockholder, for any purpose related to the Annual Meeting, for ten days prior to the Annual Meeting at our offices located at 1400 16th Street, San Francisco, California 94103. Please contact our Secretary by telephone at (415) 374-7782 if you wish to inspect the list of stockholders prior to the Annual Meeting. This list will also be available for examination by stockholders during the Annual Meeting using the 16-digit control number included in your proxy materials.
If your shares are registered directly in your name with our transfer agent, American Stock Transfer & Trust Company, LLC (“AST”), you are considered, with respect to those shares, a stockholder of record. The Notice has been sent directly to you by us.
If your shares are held in a brokerage account or by a bank or other nominee, you are considered the beneficial owner of shares held in street name. The Notice has been forwarded to you by your broker, bank or nominee who is considered, with respect to those shares, the stockholder of record.
You may vote using any of the following methods:
By Internet –— Stockholders of record may submit proxies by following the Internet voting instructions on their proxy materials prior to the Annual Meeting. Most stockholders who hold shares beneficially in street name may provide voting instructions by accessing the website specified on the voting instruction form provided by their brokers, banks or nominees. Please be aware that if you vote over the Internet, you may incur costs such as Internet access charges for which you will be responsible. The Internet voting facilities will close at 11:59 p.m., Eastern Time, the day before the meeting date.
By Telephone –— Stockholders of record may submit proxies by following the telephone voting instructions on their proxy materials prior to the Annual Meeting. Most stockholders who hold shares
INVITAE CORPORATION• 20222023 Proxy Statement 4851
beneficially in street name may provide voting instructions by telephone by calling the number specified on the voting instruction form provided by their brokers, banks or nominees. Please be aware that if you submit voting instructions by telephone, you may incur costs such as telephone access charges for which you will be responsible. The telephone voting facilities will close at 11:59 p.m., Eastern Time, the day before the meeting date.
By Mail –— If you would like to receive a paper copy of the proxy card, you must request one. Stockholders of record may submit paper proxies by completing, signing and dating the proxy card and returning it in the prepaid envelope enclosed with the proxy card. Sign your name exactly as it appears on the proxy. If you return your signed proxy but do not indicate your voting preferences, your shares will be voted on your behalf “FOR” each nominee in Proposal 1, “FOR” Proposal 2, “FOR” Proposal 3, and “FOR” Proposal 4 and “AGAINST” Proposal 5.4. Stockholders who hold shares beneficially in street name may provide voting instructions by mail by completing, signing and dating the voting instruction forms provided by their brokers, banks or other nominees.
At the Virtual Meeting –— Shares held in your name as the stockholder of record may be voted electronically at the Annual Meeting by visiting www.virtualshareholdermeeting.com/ NVTA2022NVTA2023 and using the 16-digit control number included in your proxy materials. If you have already voted previously by Internet or telephone, there is no need to vote again at the Annual Meeting unless you wish to revoke and change your vote. Shares held beneficially in street name may be voted electronically at the Annual Meeting only if you obtain a legal proxy from the broker, bank or nominee that holds your shares giving you the right to vote the shares.
Even if you plan to attend the Annual Meeting via live audio webcast, we recommend that you also submit your proxy or voting instructions or vote by Internet, telephone or mail prior to the meeting so that your vote will be counted if you later decide not to attend the meeting.
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You may change your vote or revoke your proxy at any time prior to the vote at the Annual Meeting. If you submitted your proxy by Internet or telephone, you may change your vote or revoke your proxy with a later Internet or telephone proxy, as the case may be. If you are a stockholder of record and submitted your proxy by mail, you must file with the Secretary of the Company a written notice of revocation or deliver, prior to the vote at the Annual Meeting, a valid, later-dated proxy. Attendance at the Annual Meeting will not have the effect of revoking a proxy unless you give written notice of revocation to the Secretary before the proxy is exercised or you vote at the Annual Meeting.
If you are a beneficial owner of shares held in street name and you wish to change or revoke your vote, you must obtain a legal proxy through your broker and present it to AST at least two weeks in advance of the Annual Meeting. Please consult the voting instructions or contact your broker, bank or nominee.
For Proposal 1, the election of directors, you may vote “FOR” the Class III nominees“FOR,” “AGAINST” or your vote may be “WITHHELD”“ABSTAIN” with respect to one or botheach of the nominees. “WITHHELD” votes will not affect the outcome. Broker Abstentions and broker non-votes will have no effect.effect on the outcome of director elections.
For each of Proposals 2, 3 4 and 5,4, you may vote “FOR,” vote “AGAINST” or “ABSTAIN.” An abstention has the same effect as a vote “AGAINST” any of these proposals. To the extent broker-non votes exist with respect to such proposals, they will have no effect.
If you provide specific instructions, your shares will be voted as you instruct. If you sign your proxy card or voting instruction form with no further instructions, your shares will be voted in accordance with the recommendations of our board of directors (i.e., “FOR” each nominee in Proposal 1, “FOR” each of Proposals 2, 3 and 4 and “AGAINST” Proposal 5 and on any other matters that may properly come before the meeting, in the discretion of the proxy holders.holders).
If you hold shares beneficially in street name and do not provide your broker or nominee with voting instructions, your shares may constitute “broker non-votes.” Generally, broker non-votes occur on a matter when a broker or nominee does not have discretionary voting authority to vote on that matter without instructions from the
INVITAE CORPORATION • 2022 Proxy Statement 49
beneficial owner and instructions are not given. Discretionary items are proposals considered “routine” under the rules of the NYSE, such as the ratification of the appointment of our independent auditors, and therefore, broker non-votes are not expected to exist with respect to this proposal. Except for Proposal 2, amendment to our Restated Certificate to increase the number of authorized shares of common stock, and Proposal 4, ratification of the appointment of Ernst & Young LLP as our independent
INVITAE CORPORATION • 2023 Proxy Statement 52
registered public accounting firm for the year ending December 31, 2022,2023, all other proposals to be voted on at the Annual Meeting are considered a “non-routine” item for which brokers and nominees do not have discretionary voting power and, therefore, broker non-votes may exist with respect to these proposals. In tabulating the voting result for any particular proposal, shares that constitute broker non-votes are not considered entitled to vote on that proposal. Thus, broker non-votes will not affect the outcome of any matter being voted on at the Annual Meeting, assuming that a quorum is obtained.
We have a form of majority voting standard for the election of directors in an uncontested election, which is generally defined as an election in which the number of nominees does not exceed the number of directors to be elected at the meeting. Cumulative voting is not permitted, which means that each stockholder may vote no more than the number of shares he or she owns for a single director candidate. The nominees receiving the highest number of “FOR” votes at the Annual Meeting will be elected. If any nominee for director receives a greater number of votes “WITHHELD”“AGAINST” than votes “FOR” such election, our Bylaws require that such person must promptly tender his or her irrevocable resignation to our board of directors for the board’s consideration. If such director’s resignation is accepted by the board, then our board of directors, in its sole discretion, may fill the resulting vacancy or may decrease the size of the board in accordance with the provisions of our Bylaws.
The table below describes the proposals to be considered at the Annual Meeting and the vote required for each proposal:
| Proposal | Board Recommendation | Vote Required | Effect of Abstentions(1) | Broker Discretionary Voting Allowed?(2) | |||||
| 1 Election of Directors | 
| FOReach nominee | The nominees receiving the highest number of “FOR” votes at the Annual Meeting will be elected. | No effect Not | No Brokers without voting instructions will not be able to vote on this proposal. | ||||
| 2 Proposal to |
| FOR | The affirmative “FOR” vote of a majority of the | Counted as voteSame effect as vote against | No Brokers without voting instructions will | ||||
| 3 Advisory Vote to Approve Executive Compensation |
| FOR | Non-binding, advisory proposal. We will consider the matter approved if it receives the affirmative “FOR” vote of a majority of the voting power present in person or represented by proxy at the Annual Meeting and entitled to vote. | Counted as voteSame effect as vote against | No Brokers without voting instructions will not be able to vote on this proposal. | ||||
| 4 Ratification of the Appointment of Ernst & Young LLP |
| FOR | The affirmative “FOR” vote of a majority of the voting power present in person or represented by proxy at the Annual Meeting and entitled to vote. | Counted as voteSame effect as vote against | Yes Brokers without voting instructions will have discretionary authority to vote on this proposal. | ||||
| |||||||||
| (1) | As noted below, abstentions will be counted as present for purposes of establishing a quorum at the Annual Meeting. |
| (2) | Only relevant if you are the beneficial owner of shares held in street name. If you are a stockholder of record and you do not cast your vote, no votes will be cast on your behalf on any of the items of business at the Annual Meeting. |
INVITAE CORPORATION• 20222023 Proxy Statement 5053
The presence online at the Annual Meeting or represented by proxy, of the holders of a majority of the voting power of common stock issued and outstanding and entitled to vote on the Record Date, will constitute a quorum. As of the close of business on the Record Date, 229,193,795260,674,728 shares of our common stock were outstanding. Both abstentions and broker non-votes are counted for the purpose of determining the presence of a quorum.
We have adopted a process for mailing our proxy materials called “householding” which has been approved by the SEC. Householding means that stockholders who share the same last name and address will receive only one copy of our proxy materials, unless we receive contrary instructions from any stockholder at that address.
If you prefer to receive multiple copies of our proxy materials at the same address, additional copies will be provided to you upon request. If you are a stockholder of record, you may contact us by writing to Secretary, Invitae Corporation, 1400 16th Street, San Francisco, California 94103, or by calling (415) 374-7782. Eligible stockholders of record receiving multiple copies of our proxy materials can request householding by contacting us in the same manner. We have undertaken householding to reduce printing costs and postage fees, and we encourage you to participate.
If you are a beneficial owner, you may request additional copies of our proxy materials or you may request householding by notifying your broker, bank or other nominee.
Our employees, officers and directors may solicit proxies. We will pay the cost of printing and mailing proxy materials, and will reimburse brokerage houses and other custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses for forwarding proxy material to the owners of our common stock. We have engaged Alliance Advisors, LLC, to assist us with the solicitation of proxies for a fee of $16,000$17,000 plus out-of-pocket expenses.
After careful consideration, in lightWe are proposing the NYSE Proposal because our common stock is listed on the NYSE and, as a result, we are subject to certain NYSE listing rules and regulations. Pursuant to Section 312.03(c) of the ongoing COVID-19 pandemic andNYSE Listed Company Manual, subject to protectcertain exceptions, stockholder approval is required prior to the healthissuance of our employees, stockholders andcommon stock, or of securities convertible into or exercisable for common stock, in any transaction or series of related transactions if: (1) the community,common stock has, or will have upon issuance, voting power equal to or in excess of 20% of the Annual Meetingvoting power outstanding before the issuance of such stock or of securities convertible into or exercisable for common stock or (2) the number of shares of common stock to be issued is, or will again be a completely virtual meetingupon issuance, equal to or in excess of stockholders conducted via live audio webcast.20% of the number of shares of common stock outstanding before the issuance of the common stock or of securities convertible into or exercisable for common stock. In addition, we believepursuant to Section 312.03(d) of the NYSE Listed Company Manual, stockholder approval is required for any issuance that will result in a change of control of the virtual meeting format will expandissuer. We are seeking stockholder accessapproval of the issuance of the number of shares of common stock upon conversion of the Notes and/or exercise of any Warrants issued in respect of the Notes under Section 312.03(c) and participation. You will not be able to attendSection 312.03(d) of the Annual Meeting in person. We currently expect thatNYSE Listed Company Manual. For additional information, please see the 2023 annual meeting of stockholders will be held in person.section entitled “Proposal No. 2 — The NYSE Proposal.”
If the NYSE Proposal is approved, the maximum number of shares of common stock potentially issuable in respect of the Notes and/ or any Warrants issued in respect of the Notes is 141,979,975 shares of common stock.
INVITAE CORPORATION • 2023 Proxy Statement 54
The Annual Meeting will be a completely virtual meeting of stockholders conducted exclusively via live audio webcast. You will be able to attend the Annual Meeting via live audio webcast by visiting www.virtualshareholdermeeting.com/NVTA2022.NVTA2023. To participate in, vote or ask questions at the Annual Meeting, you will also need the 16-digit control number, which is included in your proxy materials. If you have any questions about your control number, please contact the broker, bank or nominee that holds your shares. The Annual Meeting will begin promptly at 4:00 p.m., Pacific Time, on Monday, June 6, 2022.5, 2023. We encourage you to access the virtual meeting website prior to the start time. You may begin to log into the virtual meeting platform beginning at approximately 3:30 p.m., Pacific Time, on Monday, June 6, 2022.5, 2023.
We will have technicians ready to assist you with technical difficulties you may have accessing, voting at or submitting questions at the Annual Meeting. Please refer to the technical support telephone number posted on the virtual meeting website login page.
INVITAE CORPORATION• 20222023 Proxy Statement 5155
Except for the historical information set forth herein, the matters set forth in this proxy statementProxy Statement contain predictions, estimates and other forward-looking statements, including without limitation statements regarding: our mission and our business plan; expected changes in the healthcare and medical genetics industry; the impact of information from our tests; objectives of our compensation program; our business and financial goals and milestones; the potential impact of the approval of the proposalmilestones, including our path to amend our Restated Certificate to increase the number of authorized shares of common stock;operational excellence; and our plans and expectations regarding our CSR and ESG programs, strategy, initiatives and objectives, including our environmental sustainability programs and our efforts to seek diversity on our board of directors.
These forward-looking statements are based on our current expectations and are subject to risks and uncertainties that may cause actual results to differ materially, including: our ability to execute our business model; changes in applicable laws or regulations; the effect of the COVID-19 pandemic on our business; our ability to compete; the possibility that we may be adversely affected by other political or economic factors; and other risks detailed from time to time in our reports filed with the Securities and Exchange Commission,SEC, including our Annual Report on Form 10-K for the year ended December 31, 2021.2022. We disclaim any intent or obligation to update these forward-looking statements.
INVITAE CORPORATION• 20222023 Proxy Statement 5256
CERTIFICATE OF AMENDMENTIn this Proxy Statement, Invitae discloses the following non-GAAP measures: non-GAAP gross margin and non-GAAP cash burn. These non-GAAP financial measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similarly-titled measures presented by other companies. Management believes these non-GAAP financial measures are useful to investors in evaluating the Company’s ongoing operating results and trends. These non-GAAP financial measures are limited in value because they exclude certain items that may have a material impact on the Company’s reported financial results. We account for this limitation by analyzing results on a GAAP basis as well as a non-GAAP basis and also by providing GAAP measures in the Company’s public disclosures.
OF
AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
OF
INVITAE CORPORATION
Invitae Corporation,Cash burn excludes net changes in investments. We believe cash burn is a corporation organizedliquidity measure that provides useful information to management and existing underinvestors about the General Corporation Lawamount of cash consumed by the operations of the Statebusiness. A limitation of Delaware (the “Corporation”), hereby certifiesusing this non-GAAP measure is that cash burn does not represent the total change in cash, cash equivalents and restricted cash for the period because it excludes cash provided by or used for other operating, investing or financing activities. We account for this limitation by providing information about the Company’s operating, investing and financing activities in the statements of cash flows in the consolidated financial statements in the Company’s most recent Annual Report on Form 10-K and by presenting net cash provided by (used in) operating, investing and financing activities as follows:well as the net increase or decrease in cash, cash equivalents and restricted cash in its reconciliation of cash burn.
This Proxy Statement discloses the Company’s non-GAAP gross margin, a non-GAAP measure used to describe the Company’s performance. We defined non-GAAP gross margin as revenue less the non-GAAP cost of revenue, divided by revenue, where the non-GAAP cost of revenue is defined as the GAAP cost of revenue recorded in the Company’s filings with the SEC, excluding non-acquisition related items related to restructuring and the following acquisition-related expenses: (1) amortization of intangible assets; (2) stock-based compensation; (3) post-combination expenses; and (4) fair value adjustments to assets and liabilities.
“Classes of Stock. The total number of shares of all classes of capital stock thatIn addition, other companies, including companies in the Corporation shall have authoritysame industry, may not use the same non-GAAP measures or may calculate these metrics in a different manner than management or may use other financial measures to issue is Six Hundred Twenty Million (620,000,000),evaluate their performance, all of which Six Hundred Million (600,000,000) shares shallcould reduce the usefulness of these non-GAAP measures as comparative measures. Because of these limitations, the Company’s non-GAAP financial measures should not be Common Stock, $0.0001 par value per share (the “considered in isolation from, or as a substitute for, financial information prepared in accordance with GAAP. Investors are encouraged to review the non-GAAP reconciliations provided in the tables presented.
| Three Months Ended | Year ended December 31, | ||||||||||||||||||||||||
| (in thousands) (unaudited) | December 31, 2021 | March 31, 2022 | June 30, 2022 | September 30, 2022 | December 31, 2022 | 2022 | 2021 | 2020 | |||||||||||||||||
| Net cash used in operating activities | $ | (175,918) | $ | (147,543) | $ | (134,689) | $ | (128,702) | $ | (82,027) | $ | (492,961) | $ | (559,815) | $ | (298,502) | |||||||||
| Net cash provided by (used in) investing activities | 170,503 | (449,456) | 108,965 | 43,797 | 121,891 | (174,803) | (204,080) | (400,583) | |||||||||||||||||
| Net cash provided by (used in) financing activities | 7,031 | (920) | 3,770 | (1,691) | 599 | 1,758 | 1,565,940 | 672,993 | |||||||||||||||||
| Net increase(decrease) in cash, cash equivalents and restricted cash | 1,616 | (597,919) | (21,954) | (86,596) | 40,463 | (666,006) | 802,045 | (26,092) | |||||||||||||||||
| Adjustments: | |||||||||||||||||||||||||
| Net changes in investments | (197,250) | 428,608 | (125,087) | (55,212) | (82,261) | 166,048 | (99,336) | (10,061) | |||||||||||||||||
| Proceeds from public offering of common stock, net of issuance costs | – | – | – | (9,658) | – | (9,658) | (434,263) | (263,688) | |||||||||||||||||
| Proceeds from issuance of convertible senior notes, net | – | – | – | – | – | – | (1,116,427) | – | |||||||||||||||||
| Proceeds from common stock issued in private placement, net | – | – | – | – | – | – | – | (263,628) | |||||||||||||||||
| Proceeds from issuance of debt, net | – | – | – | – | – | – | – | (129,214) | |||||||||||||||||
| Proceeds from exercises of warrants | – | – | – | – | – | – | (1,242) | (974) | |||||||||||||||||
| Cash burn | $ | (195,634) | $ | (169,311) | $ | (147,041) | $ | (151,466) | $ | (41,798) | $ | (509,616) | $ | (849,223) | $ | (693,657) | |||||||||
IN WITNESS WHEREOF, the Corporation has caused this Certificate of Amendment of Amended and Restated Certificate of Incorporation to be signed by its duly authorized President and Chief Executive Officer on this ___ day of _______, 2022.
INVITAE CORPORATION• 20222023 Proxy Statement 5357
| • | Cash burn for the year ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets,$38.4 million of restructuring-related cash payments and$14.9 million of acquisition-related payments. |
| • | Cash burn for the year ended December 31, 2021 includes $281.9 million of cash paid for acquisitions and $3.3 million in acquisition-related transaction costs. |
| • | Cash burn for the year ended December 31, 2020 includes $410.4 million of cash paid for acquisitions and $13.6 million in acquisition-related transaction costs. |
| • | Cash burn for the three months ended December 31, 2021 includes $9.5 million cash paid for acquisitions. |
| • | Cash burn for the three months ended June 30, 2022 includes $0.7 million of acquisition-related payments. |
| • | Cash burn for the three months ended September 30, 2022 includes $29.1 million of restructuring-related cash payments and $14.1 million of acquisition-related payments. |
| • | Cash burn for the three months ended December 31, 2022 includes $44.5 million of proceeds from the sale of RUO kit assets, $9.3 million of restructuring-related cash payments and $0.1 million of acquisition-related payments. |
| Three Months Ended | Year ended December 31, | ||||||||||
| (in thousands) (unaudited) | March 31, 2022 | June 30, 2022 | September 30, 2022 | December 31, 2022 | 2022 | ||||||
| Revenue | $123,691 | $136,622 | $133,536 | $122,454 | $ 516,303 | ||||||
| Cost of revenue | 97,116 | 110,340 | 116,956 | 92,844 | 417,256 | ||||||
| Gross profit | 26,575 | 26,282 | 16,580 | 29,610 | 99,047 | ||||||
| Amortization of acquired intangible assets | 18,000 | 27,907 | 27,711 | 26,950 | 100,568 | ||||||
| Acquisition-related stock-based compensation | 132 | 147 | 146 | 156 | 581 | ||||||
| Acquisition-related post-combination expense | 504 | 387 | 162 | – | 1,053 | ||||||
| Restructuring-related retention bonuses | – | – | 170 | 82 | 252 | ||||||
| Inventory and prepaid write-offs | – | – | 16,467 | 1,712 | 18,179 | ||||||
| Non-GAAP gross profit | $45,211 | $54,723 | $61,236 | $58,510 | $ 219,680 | ||||||
INVITAE CORPORATION • 2023 Proxy Statement 58
